ENGLISH

Transporters in Drug Development: Discovery, Optimization, Clinical Study and Regulation

By Ph.D. (auth.) , Bente Steffansen M.Sc.(Pharm) , Yuichi Sugiyama , Bente Steffansen (eds.)

Book information

Publisher
Springer-Verlag New York
Year
2013
ISBN
978-0-12-032307-4
DOI
10.1007/978-1-4614-8229-1
ISSN
0065-3136
Language
english
Format
PDF
Filesize
5 MB (5414656 bytes)
Series
AAPS Advances in the Pharmaceutical Sciences Series 7
Edition
1
Pages
317\321
Orientation
yes
Scanned
yes
Time added
2013-09-17 06:00:55
Pharmaceutical Sciences/Technology; Biomedicine ge

Description

Transporters in Drug Development examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters’ impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.

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