DNA Repair and Human Health

Description

InTech. 2011. 806 p.Over the past decades, great advances have been made in understanding the cellular DNA repair pathways. At the same time, a wealth of descriptive knowledge of human diseases has been accumulated. Now, the basic research of the mechanisms of DNA repair is merging with clinical research, placing the action of the DNA repair pathways in the context of the whole organism. Such integrative approach enables understanding of the disease mechanisms and is invaluable in improving diagnostics and prevention, as well as designing better therapies. This book highlights the central role of DNA repair in human health and well-being. The reviews presented here, contain detailed descriptions of DNA repair pathways, as well as analysis of a large body of evidence addressing links between DNA damage repair and human health. They will be of interest to a broad audience, from molecular biologists working on DNA repair in any model system, to medical researchers.ContentsPrefaceDNA Repair MechanismsDNA Repair, Human Diseases and Aging Double Strand Break Signaling in Health and Diseases DNA Damage Repair and Cancer: The Role of RAD51 Protein and Its Genetic Variants The Role of Error-Prone Alternative Non-Homologous End-Joining in Genomic Instability in Cancer Nucleotide Excision Repair and Cancer Recombinant Viral Vectors for Investigating DNA Damage Responses and Gene Therapy of Xeroderma PigmentosumDNA Repair and CancerDNA Damage, Repair and Misrepair in Cancer and in Cancer Therapy DNA Repair, Cancer and Cancer Therapy DNA Repair, Cancer and Cancer Therapy - The Current State of Art Application of UV-Induced Unscheduled DNA-Synthesis Measurements in Human Genotoxicological Risk Assessment Hypoxia Inhibits DNA Repair to Promote Malignant Progression From the Molecular Biology to the Gene Therapy of a DNA Repair Syndrome: Fanconi Anemia Fanconi Anemia/Brca Pathway and Head and Neck Squamous Cell Carcinomas DNA Repair Deficiency Associated with Hematological Neoplasms DNA Repair in Acute Myeloid Leukemia and Myelodysplastic Syndromes Therapeutic Modulation of DNA Damage and Repair Mechanisms in Blood Cells DNA Repair Perspectives in Thyroid and Breast Cancer: The Role of DNA Repair Polymorphisms DNA Mismatch Repair (MMR) Genes and Endometrial Cancer Human Apurinic/Apyrimidinic Endonuclease is a Novel Drug Target in Cancer Disruption of Protein–DNA Interactions: An Opportunity for Cancer Chemotherapy Pharmacogenomic Approach of Telomerase in Cancer: Importance of End Zone Variability Differential Effects of the G-Quadruplex Ligand 360A in Human Normal and Cancer Cells Pharmacogenetics of Cancer and DNA Repair EnzymesDNA Repair and AgingInvolvement of Histone PTMs in DNA Repair Processes in Relation to Age-Associated Neurodegenerative Disease Transcriptional Functions of DNA Repair Proteins Involved in Premature AgingDNA Damage and DiseaseDNA Damage and mRNA Levels of DNA Base Excision Repair Enzymes Following H2O2 Challenge at Different Temperatures Relationship Between DNA Damage and Energy Metabolism: Evidence from DNA Repair Deficiency SyndromesInfection, Inflammation and DNA RepairThe Role of DNA Repair Pathways in Adeno-Associated Virus Infection and Viral Genome Replication / Recombination / Integration Integration of the DNA Damage Response with Innate Immune Pathways Non-Steroidal Anti-Inflammatory Drugs, DNA Repair and Cancer Inhibition of DNA Polymerase λ, a DNA Repair Enzyme, and Anti-Inflammation: Chemical Knockout Analysis for DNA Polymerase λ Using Curcumin Derivatives