Neurodegenerative Diseases

Description

This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, Lewy body dementia,Parkinson’s disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases. Both clinical and basic aspects of each disease are treated, including novel diagnostic criteria, old and new treatments, basic discoveries (genetics, epigenetics and molecular biology), and translation of basic research into biomarkers for early diagnosis, particularly to identify peripheral biomarkers. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis. Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields. Front Matter ....Pages i-x Genetics and Epigenetics in the Neurodegenerative Disorders of the Central Nervous System (Chiara Fenoglio)....Pages 1-20 Diagnosis of Alzheimer’s Disease Typical and Atypical Forms (Laura Ghezzi)....Pages 21-28 Genetic Complexity of Early-Onset Alzheimer’s Disease (Mahdi Ghani, Christiane Reitz, Peter St George-Hyslop, Ekaterina Rogaeva)....Pages 29-50 Genetic Risk Factors for Complex Forms of Alzheimer’s Disease (Céline Bellenguez, Jean-Charles Lambert)....Pages 51-76 Role of Cerebrovascular Disease in Cognition (Ana Verdelho)....Pages 77-92 Risk Factors and Prevention in Alzheimer’s Disease and Dementia (Giulia Grande, Davide L. Vetrano, Francesca Mangialasche)....Pages 93-112 Diagnosis of Frontotemporal Dementia (Giorgio Giulio Fumagalli)....Pages 113-121 Autosomal Dominant Frontotemporal Lobar Degeneration: From Genotype to Phenotype (Maria Serpente, Daniela Galimberti)....Pages 123-145 Genetic Risk Factors for Sporadic Frontotemporal Dementia (Raffaele Ferrari, Claudia Manzoni, Parastoo Momeni)....Pages 147-186 Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Mouse Models (Lars M. Ittner, Wei S. Lee, Kristie Stefanoska, Prita R. Asih, Yazi D. Ke)....Pages 187-219 Fluid Biomarkers in Alzheimer’s Disease and Frontotemporal Dementia (Niklas Mattsson, Sotirios Grigoriou, Henrik Zetterberg)....Pages 221-252 Biomarkers for Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Imaging (Marco Bozzali, Laura Serra)....Pages 253-277 Genotypic and Phenotypic Heterogeneity in Amyotrophic Lateral Sclerosis (Nicola Ticozzi, Vincenzo Silani)....Pages 279-295 Lewy Body Dementia (L. Bonanni, R. Franciotti, S. Delli Pizzi, A. Thomas, M. Onofrj)....Pages 297-312 Rare Dementias (Camilla Ferrari, Benedetta Nacmias, Sandro Sorbi)....Pages 313-336 Neurodevelopmental and Neurodegenerative Alterations in the Pathophysiology of Schizophrenia: Focus on Neuro-Immuno-Inflammation (Bernardo Dell’Osso, M. Carlotta Palazzo, A. Carlo Altamura)....Pages 337-348 Parkinson’s Disease: Contemporary Concepts and Clinical Management (Vanessa Carvalho, Carlota Vicente Cunha, João Massano)....Pages 349-378 Neurodegeneration and Multiple Sclerosis (Axel Petzold)....Pages 379-400 Back Matter ....Pages 401-407