ENGLISH

The Bipolar Brain: Integrating Neuroimaging and Genetics

By Stephen M. Strakowski (editor)

Book information

Publisher
Oxford University Press
Year
2012
ISBN
0199797609, 9780199797608
Language
english
Format
PDF
Filesize
7 MB (7080274 bytes)
Pages
296\295
Time added
2021-04-29 10:54:38

Description

Bipolar disorder is one of the most common, and disabling, conditions affecting human kind. Each year, millions of individuals struggle with the effects of this illness. Although clinically well recognized for decades, if not centuries, the causes of this condition remain incompletely understood. However, in the past decade, significant technological advances in both neuroimaging and genetic research have revealed clues about the neurophysiological basis of bipolar illness. In this book, leading experts in neuroimaging and genetics discuss recent discoveries in bipolar disorder that identify both the structural, functional and chemical brain changes that seem to underlie this condition, as well as the possible genetic causes of these brain events. Based upon these discussions, the book then integrates these diverse considerations to develop a specific neurophysiological model of bipolar disorder. This model provides a resource to guide clinicians and patients as they struggle to understand this illness, as well as a guide for future investigations into the causes of bipolar disorder. With this guide in hand, this book will lead to a new framework for understanding bipolar disorder in order to, ultimately, develop improved therapies for affected individuals and novel strategies to prevent the onset in children at risk for this condition. Contents Foreword • Frederick K. Goodwin Preface Contributors PART I: HOW NEUROIMAGING INFORMS MODELS OF BIPOLAR DISORDER 1. BRAIN IMAGING TECHNIQUES AND THEIR APPLICATION TO BIPOLAR DISORDER • Caleb M. Adler and Michael A. Cerullo 2. STRUCTURAL BRAIN ABNORMALITIES IN BIPOLAR DISORDER • Koji Matsuo, Marsal Sanches, Paolo Brambilla, and Jair C. Soares 3. FUNCTIONAL BRAIN IMAGING IN BIPOLAR DISORDER • Lori L. Altshuler and Jennifer D. Townsend 4. NEUROCHEMICAL AND METABOLIC IMAGING IN BIPOLAR DISORDER • Jieun E. Kim, In Kyoon Lyoo, and Perry F. Renshaw 5. NEUROIMAGING STUDIES OF BIPOLAR DISORDER IN YOUTH • Manpreet K. Singh, Melissa P. DelBello, and Kiki D. Chang 6. NEUROIMAGING STUDIES OF BIPOLAR AND UNIPOLAR DEPRESSION • Amelia Versace, Jorge R. C. Almeida, and Mary L. Phillips 7. NEUROIMAGING IN BIPOLAR DISORDER AND SCHIZOPHRENIA • Heather C. Whalley, Jessika E. Sussman, and Andrew M. McIntosh PART II: HOW GENETIC RESEARCH INFORMS MODELS OF BIPOLAR DISORDER 8. GENETIC TECHNIQUES AND THEIR APPLICATION TO BIPOLAR DISORDER • Aaron C. Vederman and Melvin G. McInnis 9. GENERAL GENETICS OF BIPOLAR DISORDER • John I. Nurnberger, Jr. 10. GENETICS OF BIPOLAR DISORDER AND SCHIZOPHRENIA • Michael E. Talkowski, Kodavali V. Chowdari, Hader Mansour, Konasale M. Prasad, Joel Wood, and Vishwajit L. Nimgaonkar 11. MITOCHONDRIAL GENETICS ANDBIPOLAR DISORDER • Hayley B. Clay, Satoshi Fuke, Tadafumi Kato, and Christine Konradi PART III: INTEGRATION AND FUTURE DIRECTIONS 12. INTEGRATING IMAGING AND GENETIC RESEARCH: TOWARD PERSONALIZED MEDICINE • Roy H. Perlis and Hilary P. Blumberg 13. INTEGRATION AND CONSOLIDATION: A NEUROPHYSIOLOGICAL MODEL OF BIPOLAR DISORDER • Stephen M. Strakowski Index

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