ENGLISH

Diabetic Nephropathy: Pathophysiology and Clinical Aspects

By Joris J. Roelofs , Liffert Vogt

Book information

Publisher
Springer International Publishing
Year
2019
ISBN
978-3-319-93520-1, 978-3-319-93521-8
Language
english
Format
PDF
Filesize
14 MB (14373936 bytes)
Edition
1st ed.
Pages
XVI, 548\540
Time added
2019-01-12 07:48:43
Medicine & Public Health; Diabetes; Pathology

Description

This book provides an overview of the most up-to-date research on diabetic nephropathy and the current understanding of its pathogenesis, clinical features and socio-economic developments. Written by leading experts in the field, it provides a comprehensive synthesis of clinical and pathophysiological aspects from a mechanism-based point of view, and reviews evidence-based treatment modalities for the prevention and management of diabetic nephropathy. In addition, closely related areas such as diabesity, diabetic eye disease and macrovascular involvement in diabetes are addressed. Diabetic Nephropathy will be of interest for nephrologists, diabetologists, internists, transplant physicians, public health professionals, basic scientists, geneticists, epidemiologists, pathologists, and molecular and cell biologists working in the field of diabetes and its complications. Front Matter ....Pages i-xvi Front Matter ....Pages 1-1 A Historical Overview of Diabetic Nephropathy (Garabed Eknoyan)....Pages 3-19 Clinical Features and Natural Course of Diabetic Nephropathy (Peter Rossing, Marie Frimodt-Møller)....Pages 21-32 Global, Regional, and Ethnic Differences in Diabetic Nephropathy (Oluwatoyin I. Ameh, Ikechi G. Okpechi, Charles Agyemang, Andre P. Kengne)....Pages 33-44 Diabetic Nephropathy in Children and Adolescents (Petter Bjornstad)....Pages 45-64 Renal Disease in Obesity, Metabolic Syndrome and Diabesity (Esteban Porrini, Maruja Navarro-Díaz, Rosa Rodríguez-Rodríguez, Eduardo Salido)....Pages 65-80 Front Matter ....Pages 81-81 Introduction to Pathogenetic Mechanisms of Diabetic Nephropathy (Liffert Vogt, Joris J. Roelofs)....Pages 83-87 The Genetics of Diabetic Nephropathy (Marcus G. Pezzolesi, Andrzej S. Krolewski)....Pages 89-112 Pathology of the Kidney in Diabetes (Behzad Najafian, Charles E. Alpers)....Pages 113-140 Front Matter ....Pages 141-141 The Mesangial Cell in Diabetic Nephropathy (Tri Q. Nguyen, Roel Goldschmeding)....Pages 143-151 The Glomerular Endothelium in Diabetic Nephropathy: Role of Heparanase (Johan van der Vlag, Baranca Buijsers)....Pages 153-170 The Podocyte in Diabetic Nephropathy: Recent Advances (Gavin I. Welsh, Richard J. Coward)....Pages 171-182 Inflammatory Processes in Diabetic Glomeruli (Daphne H. T. IJpelaar)....Pages 183-194 Front Matter ....Pages 195-195 Proteinuria and Tubulotoxicity (Norberto Perico, Ariela Benigni, Giuseppe Remuzzi)....Pages 197-214 Tubuloglomerular Communication in Diabetic Nephropathy (Shu Wakino, Kazuhiro Hasegawa, Hiroshi Itoh)....Pages 215-226 Mechanisms of Interstitial Fibrosis in Diabetic Nephropathy (Ivonne Loeffler, Gunter Wolf)....Pages 227-251 Front Matter ....Pages 253-253 Microvascular Damage and Hemodynamic Alterations in Diabetic Nephropathy (Eliane F. E. Wenstedt, Liffert Vogt)....Pages 255-276 Coagulation and Hemostasis in Diabetic Nephropathy (Joris J. Roelofs)....Pages 277-291 Renal Hemodynamics in Diabetic Kidney Disease: Relevance for Intervention (Marco van Londen, Niek Hessels, Annebelle Michielsen, Nicolien Kasper, Gerjan Navis)....Pages 293-304 Microvascular Complications in the Eye: Diabetic Retinopathy (Esmeralda K. Bosma, Cornelis J. F. van Noorden, Ingeborg Klaassen, Reinier O. Schlingemann)....Pages 305-321 Front Matter ....Pages 323-323 Hypertension in Diabetic Kidney Disease (Gema Ruiz-Hurtado, Luis M. Ruilope)....Pages 325-335 Macrovascular Involvement in Diabetes: Renal Artery Stenosis (Bert-Jan van den Born, Fouad Amraoui)....Pages 337-355 Atherosclerosis and Diabetic Nephropathy (Raphael Duivenvoorden)....Pages 357-372 Front Matter ....Pages 373-373 Animal Models of Diabetic Kidney Disease (Isabel Nguyen, Arianne van Koppen, Jaap A. Joles)....Pages 375-413 (Clinical) Trial and Error in Diabetic Nephropathy (Marjolein Y. A. M. Kroonen, Hiddo J. L. Heerspink, Dick de Zeeuw)....Pages 415-431 Front Matter ....Pages 433-433 Treatment Goals in Diabetic Nephropathy (Gerald Vervoort)....Pages 435-450 Kidney Transplantation and Diabetic Nephropathy (Jesper Kers, Frederike J. Bemelman)....Pages 451-467 Front Matter ....Pages 469-469 Health Programmes in Low- and Middle-Income Countries (Maria Pallayova, Gopesh K. Modi, Indranil Dasgupta)....Pages 471-486 Omics in Diabetic Kidney Disease (Massimo Papale, Francesca Conserva, Paola Pontrelli, Loreto Gesualdo)....Pages 487-513 Future and Novel Compounds in the Treatment of Diabetic Nephropathy (Nienke M. A. Idzerda, Michelle J. Pena, Dick de Zeeuw, Hiddo J. L. Heerspink)....Pages 515-539 Back Matter ....Pages 541-548

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