Innovative Treatment Strategies for Clinical Electrophysiology

Description

This book highlights the advancements in different fields of clinical electrophysiology and gives the reader a good background of the established practices. To tackle such a wide topic, the book focuses on two main aspects: ablation and pacing, discussing the novel energy sources and approaches to rhythm restoration and control; devices and signal processing, highlighting the new available technologies and numerical approaches aiding practice and home medicine. It also presents the reader with selected strategies that could be a paradigm shifts for the field: in situ cell reprogramming, exploiting the newly founded achievements in epigenetic modification of somatic cells; artificial intelligence; cardiac digital twinning, which aims to collect the information from imaging, mechanics and electrophysiology and condense it into a patient-specific model for personalized treatment. Contents Stereotactic Radioablation for Treatment of Ventricular Tachycardia 1 Introduction 2 Mechanisms of Scar-Related Ventricular Tachycardia and Radiofrequency Catheter Ablation Treatment 3 Basic Principles of STAR and Pre-clinical Studies 4 Clinical Studies 4.1 Treatment Efficacy 4.2 Treatment Safety 5 STAR Diagnostic Workup 5.1 Cardiovascular Evaluation 5.2 Radiotherapy Planning and Delivery 6 Ongoing Trials and Registries References Pulsed Field Ablation for the Interventional Treatment of Cardiac Arrhythmias 1 Introduction 2 From Irreversible Electroporation to Pulsed Field Ablation 2.1 Preclinical Investigation 2.2 Clinical Investigation 3 Modeling Electroporation to Aid Clinical Therapy 4 Current Open Issues with Pulsed Field Ablation and Conclusions References High-Power Short-Duration Radiofrequency Ablation of Atrial Fibrillation 1 Introduction 2 RF Lesion Formation 3 HPSD Ablation Characteristic 4 HPSD Ablation Outcomes 5 Safety of HPSD Ablation 6 Limitations of HPSD Ablation 7 Conclusions References The Evolving Role of the Cardiac Conduction System in Cardiac Resynchronisation Therapy and Cardiac Pacing 1 Introduction 2 Conduction System Pacing for Cardiac Resynchronisation 2.1 Anatomy of the Conduction System 2.2 Implantation Procedure 2.3 Types of Capture and ECG Characteristics of CSP 2.4 CSP in LBBB 2.5 CSP in Non-LBBB 2.6 CSP in Patients with Pacing-Induced Cardiomyopathy 2.7 CSP as Prevention of Pacing-Induced Cardiomyopathy When a High Ventricular Pacing Burden is Expected 2.8 CSP Testing and Device Programming 2.9 CSP Limitations 3 Conclusions References Cardiac Contractility Modulation as a Novel Therapy for Patients with Heart Failure 1 Definition 2 Epidemiology of Heart Failure 3 Heart Failure and Cardiac Implantable Electronic Devices 4 History 5 Indications 6 Pathophysiology and Mechanism of Action 7 Implantation Procedure and Maintenance 8 Clinical Trials 9 CCM in Patients with HF and Preserved LVEF 10 Economic Burden of CCM Therapy 11 Summary References Machine Learning for Clinical Electrophysiology 1 Introduction 2 ECG and Body Surface Potential Maps 3 Intracardiac Signals 4 Images 5 Further Types of Data 6 Outlook and Conclusion References Cardiac Digital Twin Modeling 1 Introduction 2 Construction of Anatomical Models 2.1 Geometrical Model Acquisition 2.2 Model Augmentation 3 Functional Twinning 3.1 Cellular Characteristics 3.2 Tissue Characteristics 4 Applications in Risk Prediction and Therapy Planning 4.1 Prediction of Ablation Targets for Atrial Fibrillation and Atrial Flutter 4.2 Prediction of Sudden Cardiac Death Risk 4.3 Optimal Electrode and Implantable Cardioverter Defibrillator Placement Evaluation 4.4 Ablation of Ventricular Tachycardia 5 Outlook and Conclusion References