Developments and Applications of Calcium Phosphate Bone Cements

Description

This book presents a state-of-the-art review of the latest advances in developing calcium- phosphate bone cements and their applications. It covers the synthesis methods, characterization approaches, material modification and novel binders, as well as the fabrication technologies of calcium-phosphate-based biomaterials in regenerative medicine and their clinical applications. It also highlights methodologies for fabricating scaffolds, biofunctional surfaces/interfaces and subsequently modulating the host response to implantable/injectable materials, and integrates a series of discussions and insights into calcium-phosphate cements and constructs in bone regenerative medicine. As such, the book not only covers the fundamentals but also opens new avenues for meeting future challenges in research and clinical applications. Front Matter ....Pages i-xii Calcium Phosphate Bone Cements: Their Development and Clinical Applications (Fangping Chen, Xiaoyu Ma, Yuanman Yu, Changsheng Liu)....Pages 1-39 Self-Setting Calcium Orthophosphate (CaPO4) Formulations (Sergey V. Dorozhkin)....Pages 41-146 Injectable Calcium Phosphate Cements for Hard Tissue Repair (Fangping Chen, Yuanman Yu, Xiaoyu Ma, Changsheng Liu)....Pages 147-186 Calcium Phosphate Composite Cement (Jing Wang, Changsheng Liu)....Pages 187-226 Accelerating Biodegradation of Calcium Phosphate Cement (Hongyan He, Zhongqian Qiao, Changsheng Liu)....Pages 227-255 Bioactivation of Calcium Phosphate Cement by Growth Factors and Their Applications (Yifan Ma, Baolin Huang, Dan Lin, Yuan Yuan, Changsheng Liu)....Pages 257-298 Drug-Loading Calcium Phosphate Cements for Medical Applications (Shuxin Qu, Jie Weng, Ke Duan, Yumei Liu)....Pages 299-332 Biomimetic Ion-Substituted Calcium Phosphates (Jun Ma, Shenglong Tan, Shengmin Zhang)....Pages 333-353 Nanodimensional and Nanocrystalline Calcium Orthophosphates (Sergey V. Dorozhkin)....Pages 355-448 Calcium Phosphate-Silk Fibroin Composites: Bone Cement and Beyond (Fengxuan Han, Chen Shi, Huilin Yang, Bin Li)....Pages 449-472 Importance of Biomaterials In Vivo Microenvironment pH (μe-pH) in the Regeneration Process of Osteoporotic Bone Defects (Wenlong Liu, Xiuli Dan, William Weijia Lu, Haobo Pan)....Pages 473-495 3D Printing of Calcium Phosphate Bio-scaffolds for Bone Therapy and Regeneration (Hongshi Ma, Jiang Chang, Chengtie Wu)....Pages 497-516 Development of Biodegradable Bone Graft Substitutes Using 3D Printing (Zhidao Xia, Yunsong Shi, Hongyan He, Yuanzhong Pan, Changsheng Liu)....Pages 517-545 Preparation of Collagen/Calcium Phosphate Coatings and Evaluation of Their Biological Performances (Cheng Kui, Jun Lin, Wenjian Weng)....Pages 547-596 Preclinical and Clinical Assessments of Calcium Phosphate Bone Cements (Lingyan Cao, Deliang Zeng, Shuxian Lin, Xiao Wang, Xiangkai Zhang, Ao Zheng et al.)....Pages 597-624