ENGLISH

The Adenosine Receptors

By Pier Andrea Borea , Katia Varani , Stefania Gessi , Stefania Merighi , Fabrizio Vincenzi

Book information

Publisher
Springer International Publishing;Humana Press
Year
2018
ISBN
978-3-319-90807-6, 978-3-319-90808-3
Language
english
Format
PDF
Filesize
12 MB (12964305 bytes)
Series
The Receptors 34
Edition
1st ed.
Pages
XX, 593\603
Time added
2018-08-15 07:07:45
Biomedicine; Neurochemistry

Description

This book traces the history of adenosine receptor research from molecular biology to medicinal chemistry to behavior, including their implications in disease and potential strategies as therapeutic targets. It provides the reader with a comprehensive overview of the adenosine receptors that includes information on all subtypes - A1, A2A, A2B and A3. Aspects addressed include the most up to date information on their functional distribution in the nervous and peripheral systems, behavioral roles in inflammation, cancer, pain and neurological diseases such as Huntington’s disease, Epilepsy, Parkinson’s disease and Alzheimer’s disease. Front Matter ....Pages i-xx Adenosine Receptors: The Status of the Art (Stefania Gessi, Stefania Merighi, Katia Varani)....Pages 1-11 Regulation of Extracellular Adenosine (Detlev Boison)....Pages 13-32 Adenosine Receptors: Structure, Distribution, and Signal Transduction (Stefania Merighi, Stefania Gessi, Pier Andrea Borea)....Pages 33-57 A1 Adenosine Receptor Agonists, Antagonists, and Allosteric Modulators (Zhan-Guo Gao, Dilip K. Tosh, Shanu Jain, Jinha Yu, Rama R. Suresh, Kenneth A. Jacobson)....Pages 59-89 A2A Adenosine Receptor: Structures, Modeling, and Medicinal Chemistry (Stefania Baraldi, Pier Giovanni Baraldi, Paola Oliva, Kiran S. Toti, Antonella Ciancetta, Kenneth A. Jacobson)....Pages 91-136 Medicinal Chemistry of A2B Adenosine Receptors (Christa E. Müller, Younis Baqi, Sonja Hinz, Vigneshwaran Namasivayam)....Pages 137-168 Medicinal Chemistry of the A3 Adenosine Receptor (Kenneth A. Jacobson, Dilip K. Tosh, Zhan-Guo Gao, Jinha Yu, Rama R. Suresh, Harsha Rao et al.)....Pages 169-198 Binding Thermodynamic Characteristics of Adenosine Receptor Ligands (Fabrizio Vincenzi, Katia Varani, Pier Andrea Borea)....Pages 199-215 Adenosine Receptors and Neuroinflammation (Antonella Ferrante, Roberta De Simone, Maria Antonietta Ajmone-Cat, Luisa Minghetti, Patrizia Popoli)....Pages 217-237 Adenosine Receptors as a Paradigm to Identify Dimer/Oligomers of G-Protein-Coupled Receptors and as Targets in Parkinson’s Disease and Schizophrenia (Gemma Navarro, Dasiel O. Borroto-Escuela, Kiell Fuxe, Rafael Franco)....Pages 239-258 Adenosine Receptors in Alzheimer’s Disease (Paula M. Canas, Rodrigo A. Cunha, Paula Agostinho)....Pages 259-280 What Is the Role of Adenosine Tone and Adenosine Receptors in Huntington’s Disease? (David Blum, En Chiang Chern, Maria Rosaria Domenici, Luc Buée, Ching Yeh Lin, Sergi Ferré et al.)....Pages 281-308 Role of Adenosine Receptors in Epileptic Seizures (Diogo Miguel Rombo, Joaquim Alexandre Ribeiro, Ana Maria Sebastião)....Pages 309-350 Adenosine and Oxygen/Glucose Deprivation in the Brain (Felicita Pedata, Ilaria Dettori, Lisa Gaviano, Elisabetta Coppi, Anna Maria Pugliese)....Pages 351-378 The Adenosine Receptor: A Homeostatic Neuromodulator for Fine-Tuning Control of Cognition (Jiang-Fan Chen)....Pages 379-411 The Adenosine-Receptor Axis in Chronic Pain (Daniela Salvemini, Timothy M. Doyle, Tally M. Largent-Milnes, Todd W. Vanderah)....Pages 413-437 Adenosine Signalling in the Injured Heart (Julia Hesse, Christina Alter, Jürgen Schrader)....Pages 439-460 Adenosine Receptors in the Lungs (Amir Pelleg, Riccardo Polosa)....Pages 461-470 Renal Adenosine in Health and Disease (H. Thomas Lee, Jurgen Schnermann)....Pages 471-498 Adenosine Regulation of the Immune System (Luca Antonioli, Matteo Fornai, Corrado Blandizzi, György Haskó)....Pages 499-514 Adenosine Receptors Regulate Bone Remodeling and Cartilage Physiology (Carmen Corciulo, Natasha Irrera, Bruce Neil Cronstein)....Pages 515-527 Adenosine Receptors in Gestational Diabetes Mellitus and Maternal Obesity in Pregnancy (Fabián Pardo, Luis Sobrevia)....Pages 529-542 Adenosine Receptors and Current Opportunities to Treat Cancer (Stefania Gessi, Stefania Merighi, Pier Andrea Borea, Shira Cohen, Pnina Fishman)....Pages 543-555 Role of Adenosine Receptors in Clinical Biophysics Based on Pulsed Electromagnetic Fields (Katia Varani, Fabrizio Vincenzi, Matteo Cadossi, Stefania Setti, Pier Andrea Borea, Ruggero Cadossi)....Pages 557-580 Back Matter ....Pages 581-593

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