ENGLISH

HIV Vaccines and Cure

By Linqi Zhang , Sharon R. Lewin

Book information

Publisher
Springer Singapore
Year
2018
ISBN
978-981-13-0483-5, 978-981-13-0484-2
Language
english
Format
PDF
Filesize
6 MB (6118563 bytes)
Series
Advances in Experimental Medicine and Biology 1075
Edition
1st ed.
Pages
XV, 318\325
Time added
2018-08-15 07:07:45
Biomedicine; Virology; Vaccine; Immunology; Animal

Description

This book provides a comprehensive review of the major barriers to HIV cure and vaccine. It covers the fundamental virology and immunology leading to HIV transmission, protection from infection and long term HIV persistence on antiretroviral therapy. In addition, strategies being tested to eliminate persistent HIV and the rational design of vaccines to induce protective immunity are covered. This book also discusses the challenges related to the design of clinical trials for testing the safety and efficacy of these innovative approaches. This book will provide a systematic overview and also discuss controversial issues for researchers in virology and immunology, as well as practicing physicians, and scientists in the pharmaceutical industry. Front Matter ....Pages i-xv Front Matter ....Pages 1-1 HIV Vaccine Efficacy Trials: RV144 and Beyond (Elizabeth Heger, Alexandra Schuetz, Sandhya Vasan)....Pages 3-30 HIV T-Cell Vaccines (Beatriz Mothe, Christian Brander)....Pages 31-51 HIV Broadly Neutralizing Antibodies: VRC01 and Beyond (Xueling Wu)....Pages 53-72 Structural Features of Broadly Neutralizing Antibodies and Rational Design of Vaccine (Tongqing Zhou, Kai Xu)....Pages 73-95 Monkey Models and HIV Vaccine Research (Zhiwei Chen)....Pages 97-124 Treatment of HIV for the Prevention of Transmission in Discordant Couples and at the Population Level (M. Kumi Smith, Britta L. Jewell, Timothy B. Hallett, Myron S. Cohen)....Pages 125-162 Front Matter ....Pages 163-163 HIV Persistence on Antiretroviral Therapy and Barriers to a Cure (Julia Marsh Sung, David M. Margolis)....Pages 165-185 The Molecular Biology of HIV Latency (Georges Khoury, Gilles Darcis, Michelle Y. Lee, Sophie Bouchat, Benoit Van Driessche, Damian F. J. Purcell et al.)....Pages 187-212 Cellular Determinants of HIV Persistence on Antiretroviral Therapy (Anastassia Mikhailova, Jose Carlos Valle-Casuso, Asier Sáez-Cirión)....Pages 213-239 In Vitro and In Vivo Models of HIV Latency (James B. Whitney, R. Brad Jones)....Pages 241-263 Measuring HIV Persistence on Antiretroviral Therapy (Bethany A. Horsburgh, Sarah Palmer)....Pages 265-284 Clinical Interventions in HIV Cure Research (Thomas Aagaard Rasmussen, Ole S. Søgaard)....Pages 285-318

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