Understanding Depression : Volume 1. Biomedical and Neurobiological Background

Description

This book, in two volumes, focuses on contemporary issues and dilemmas in relation to depression. The aim is to equip readers with an up-to-date understanding of the clinical and neurobiological underpinnings of depression and their relation to clinical manifestations and the development of more effective treatments. This first volume is devoted specifically to biomedical and neurobiological issues. Detailed information is presented on a wide range of topics, including genetics, molecular and cellular biology, and aspects at the neural circuit and multicellular system levels. Readers will gain a deeper appreciation of the factors and interactions underlying individual variation in responsiveness to stress and vulnerability to depression, as well as a clear understanding of potential treatment targets and causes of treatment resistance based on the latest research. A concluding section considers progress towards precision psychiatry and gender and cultural differences in depression. The companion volume is dedicated to clinical and management issues in depression. Understanding Depression will be an excellent source of information for both researchers and practitioners in the field. Front Matter ....Pages i-xiii Front Matter ....Pages 1-1 Highlights on Pharmacogenetics and Pharmacogenomics in Depression (Chiara Fabbri, Alessandro Serretti)....Pages 3-16 Imaging Genetics Studies on Susceptibility Genes for Major Depressive Disorder, the Present and the Future (Eunsoo Won, Byung Joo Ham, Yong-Ku Kim)....Pages 17-39 Gene-Environment Interactions and Role of Epigenetics in Depression (Eugene Lin, Shih-Jen Tsai)....Pages 41-50 miRNAs As Critical Epigenetic Players in Determining Neurobiological Correlates of Major Depressive Disorder (Bhaskar Roy, Yogesh Dwivedi)....Pages 51-69 The Role of Early Life Stress in HPA Axis and Depression (Mario F. Juruena, Anthony J. Cleare, Allan H. Young)....Pages 71-80 Front Matter ....Pages 81-81 Complex Role of the Serotonin Receptors in Depression: Implications for Treatment (Meysam Amidfar, Lejla Colic, Martin Walter, Yong-Ku Kim)....Pages 83-95 Emerging Role of Glutamate Receptors in Pathophysiology of Depression (Kyoung-Sae Na, Yong-Ku Kim)....Pages 97-105 New Perspective on mTOR Pathways: A New Target of Depression (Gislaine Z. Réus, Zuleide M. Ignácio, Helena M. Abelaira, João Quevedo)....Pages 107-114 Biological Markers to Differentiate the Subtypes of Depression (Je-Yeon Yun, Seung-Hwan Lee)....Pages 115-128 Front Matter ....Pages 129-129 Structural, Functional, and Molecular Neuroimaging in Depression (Kai Zhang, Jing Huang, Jin Feng, Hong Zhang, Mei Tian)....Pages 131-143 Why Do We Need Psychopathology? From the Brain’s Resting State to “Spatiotemporal Psychopathology” of Depression (Georg Northoff)....Pages 145-152 Neuroimaging in Depression: A Tool Toward Individualized Prediction of Treatment Outcome (Boudewijn J. H. B. de Pont, Jeroen A. Van Waarde, Guido A. van Wingen)....Pages 153-160 Cortical–Subcortical Interactions in the Pathophysiology of Depression (Kang Soo Lee, Sang Hyuk Lee)....Pages 161-165 Pathophysiology and Treatment Strategies for Different Types of Depression (Hwa-Young Lee, Yong-Ku Kim)....Pages 167-176 The Effect of Neurostimulation in Depression (Rafael C. R. Freire, Antonio E. Nardi)....Pages 177-187 Front Matter ....Pages 189-189 Chronic Inflammation and Resulting Neuroprogression in Major Depression (Brian E. Leonard)....Pages 191-196 Gut-Microbiota-Brain Axis and Depression (Alper Evrensel, Mehmet Emin Ceylan)....Pages 197-207 Modulating Microglial Activation As a Possible Therapeutic Target for Depression (Mina Sato-Kasai, Takahiro A. Kato, Masahiro Ohgidani, Hideki Horikawa, Yoshito Mizoguchi, Akira Monji et al.)....Pages 209-219 Experimental Animal Models for Depressive Disorders: Relevance to Drug Discovery (Boldizsár Czéh, Ove Wiborg, Eberhard Fuchs)....Pages 221-231 The Use of Animal Models in Defining Antidepressant Response: A Translational Approach (Michel Bourin)....Pages 233-242 Front Matter ....Pages 243-243 Precision Psychiatry: Personalized Clinical Approach to Depression (Giampaolo Perna, Raffaele Balletta, Charles B. Nemeroff)....Pages 245-261 Risk Factors and Prevention Strategies for Depression in Childhood and Adolescence (Jun Won Kim, Jae-Won Kim)....Pages 263-278 Neurobiology and Risk Factors of Late-Life Depression (Neha Jain, David C. Steffens)....Pages 279-295 Gender Differences in Depression (Seoyoung Yoon, Yong-Ku Kim)....Pages 297-307 An Update on the Epidemiology of Major Depressive Disorder Across Cultures (Joao P. De Aquino, Alicia Londono, André F. Carvalho)....Pages 309-315 Back Matter ....Pages 317-322