Computational Neurology and Psychiatry

Description

This book presents the latest research in computational methods for modeling and simulating brain disorders. In particular, it shows how mathematical models can be used to study the relationship between a given disorder and the specific brain structure associated with that disorder. It also describes the emerging field of computational psychiatry, including the study of pathological behavior due to impaired functional connectivity, pathophysiological activity, and/or aberrant decision-making. Further, it discusses the data analysis techniques that will be required to analyze the increasing amount of data being generated about the brain. Lastly, the book offers some tips on the application of computational models in the field of quantitative systems pharmacology. Mainly written for computational scientists eager to discover new application fields for their model, this book also benefits neurologists and psychiatrists wanting to learn about new methods. Front Matter....Pages i-vi Introduction....Pages 1-10 Outgrowing Neurological Diseases: Microcircuits, Conduction Delay and Childhood Absence Epilepsy....Pages 11-47 Extracellular Potassium and Focal Seizures—Insight from In Silico Study....Pages 49-72 Time Series and Interactions: Data Processing in Epilepsy Research....Pages 73-91 Connecting Epilepsy and Alzheimer’s Disease: Modeling of Normal and Pathological Rhythmicity and Synaptic Plasticity Related to Amyloid \(\beta \) (A \(\beta \) ) Effects....Pages 93-120 Dynamic Causal Modelling of Dynamic Dysfunction in NMDA-Receptor Antibody Encephalitis....Pages 121-148 Oscillatory Neural Models of the Basal Ganglia for Action Selection in Healthy and Parkinsonian Cases....Pages 149-189 Mathematical Models of Neuromodulation and Implications for Neurology and Psychiatry....Pages 191-225 Attachment Modelling: From Observations to Scenarios to Designs....Pages 227-271 Self-attachment: A Holistic Approach to Computational Psychiatry....Pages 273-314 A Comparison of Mathematical Models of Mood in Bipolar Disorder....Pages 315-341 Computational Neuroscience of Timing, Plasticity and Function in Cerebellum Microcircuits....Pages 343-371 A Computational Model of Neural Synchronization in Striatum....Pages 373-403 A Neural Mass Computational Framework to Study Synaptic Mechanisms Underlying Alpha and Theta Rhythms....Pages 405-427 The Role of Simulations in Neuropharmacology....Pages 429-448