Neural cell biology

Description

This book delineates how systems biology, pharmacogenomic, and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model. The text reviews and discusses approaches that can be used as effective tools to dissect mechanisms underlying pharmacological and toxicological phenomena associated with the exposure to drugs or environmental toxicants during development. The book intends to elaborate functional outcomes of component-to-component relationships using rodent and nonhuman primate in vitro and in vivo models that allow for the directional and quantitative description of the complete organism in response to environmental perturbations. In addition, attention has also been directed to some of the more recent methodologies, including genomics, proteomics and metabolomics, applied in the evolutionary neurobiological field. Content: Neurons -- nerve cells / Fang Liu, Tucker A. Patterson, Jingshu Zhang, Merle G. Paule, William Slikker, Jr., and Cheng Wang -- Astrocytes / Cheng Wang, Qi Yin, Shuliang Liu, Xuan Zhang, Fang Liu, Jingshu Zhang, Tucker A. Patterson, Merle G. Paule, and William Slikker, Jr. -- Oligodendrocytes [myelin-related glial cell in the central nervous system (CNS)] / Shuliang Liu, Merle G. Paule, Fang Liu, Qi Yin, Tucker A. Patterson, William Slikker, Jr., and Cheng Wang -- Schwann cells / Xuan Zhang, Tucker A. Patterson, Merle G. Paule, Cheng Wang, and William Slikker, Jr. -- Neuroendocrine cells / Zhen He, Sherry A. Ferguson, Tucker A. Patterson, and Merle G. Paule -- Neural stem cells in the adult brain : altered activity in aging, Alzheimer's disease, mood disorders, and epilepsy / Ashok K. Shetty and Bharathi Hattiangady -- Neural stem cells and transplantation / Malathi Srivatsan -- 3D in vitro models for developmental neurotoxicity (DNT) / Luc Stoppini, Jenny Sandström von Tobel, Igor Charvet, Marie-Gabrielle Zurich, Lars Sundstrom, and Florianne Monnet-Tschudi -- Neural cell lines (lineage) / Qiang Gu -- Advanced cell techniques to study developmental neurobiology and toxicology / Thomas Hartung, Helena T. Hogberg, Marcel Leist, David Pamies, and Lena Smirnova -- Anesthesia and neural plasticity / Laszlo Vutskits -- Blood-brain barrier (BBB) / Balabhaskar Prabhakarpandian, Syed Ali, and Kapil Pant -- Neurotrophins and Alzheimer's disease / Jyotshna Kanungo -- Neurotransmitters and receptors / Vesna Jevtovic-Todorovic -- Neuronal ion channels / Slobodan M. Todorovic -- Brain injury-neuroprotection / Koichi Yuki, Mary Ellen McCann, and Sulpicio G. Soriano.