ENGLISH

Bioorganometallic Chemistry

By Philip A. Butler , Bernhard Kräutler (auth.) , Gérard Simonneaux (eds.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
2006
ISBN
9783540330479, 354033047X
DOI
10.1007/b97910
Open Library ID
OL9056391M
Language
english
Format
PDF
Filesize
3 MB (3497258 bytes)
Series
Topics in Organometallic Chemistry 17
Edition
1
Pages
222\234
Library
kolxoz-dop
Time added
2010-02-18 13:16:04
general; Medicinal ChemistryOrganometallic Chemistry; Inorganic Chemistry; Cat

Description

Bioorganometallic Chemistry has become a mature area of science and is comprehensively covered by leading experts in this book. Naturally occuring bioorganometallic complexes, such as vitamin B12 and recently discovered iron and nickel hydrogenases, including a possible role of the latter in the geochemical theory of the origin of life, are considered. The possible formation of carbene complexes of cytochrome P450 enzymes in various metabolisms of xenobiotics is also discussed. The bioorganometallic chemistry is considered to provide not only organometallic receptors such as polynuclear organometallic macrocycles for biologically interesting molecules but also ferrocene-peptide bioconjugates giving a peptidomimetic basis for protein folding. The medicinal properties of organometallic compounds are reviewed, with notable applications in the treatment and diagnosis of cancer and in the treatment of viral, fungal, bacterial and parasitic infections. Therefore the reader will get a balanced view of this rapidly developing and promising area.

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