ENGLISH

Myofibrillogenesis

By Joseph W. Sanger , Jean M. Sanger (auth.) , Dipak K. Dube (eds.)

Book information

Publisher
Birkhäuser Basel
Year
2002
ISBN
978-1-4612-6658-7, 978-1-4612-0199-1
DOI
10.1007/978-1-4612-0199-1
Language
english
Format
PDF
Filesize
8 MB (8659605 bytes)
Series
Cardiovascular Molecular Morphogenesis
Edition
1
Pages
270\280
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00
Animal Anatomy / Morphology / Histology; Cell Biol

Description

Myofibrillogenesis has been studied extensively over the last 100 years. Until recently, we have not had a comprehensive understanding of this fundamental process. The emergence of new technologies in molecular and cellular biology, combined with classical embryology, have started to unravel some of the complexities of myofibril assembly in striated muscles. In striated muscles, the contractile proteins are arranged in a highly ordered three dimensional lattice known as the sarcomere. The assembly of a myofibril involves the precise ordering of several proteins into a linear array of sarcomeres. Multiple isoforms in many of these proteins further complicate the process, making it difficult to define the precise role of each component. This volume has been compiled as a comprehensive reference on myofibrillogenesis. In addition, the book includes reviews on myofibrillar disarray under various pathological conditions, such as familial hypertrophic cardiomyopathy (FHC), and incorporates a section on the conduction system in the heart. Much of the information in this volume has not been described elsewhere. Presented in a manner to be of value to students and teachers alike, "Myofibrillogenesis" will be an invaluable reference source for all in the fields of muscle biology and heart development.

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