ENGLISH

Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions

By Seyed Ehtesham Hasnain , Nasreen Z. Ehtesham , Sonam Grover

Book information

Publisher
Springer Singapore
Year
2019
ISBN
978-981-32-9412-7, 978-981-32-9413-4
Language
english
Format
PDF
Filesize
11 MB (11591243 bytes)
Edition
1st ed. 2019
Pages
XXII, 514\522
Time added
2020-02-08 04:43:15
Biomedicine; Parasitology; Infectious Diseases; Po

Description

This book reviews recent advances in the molecular and infection biology, pathology, and molecular epidemiology of Mycobacterium tuberculosis, as well as the identification and validation of novel molecular drug targets for the treatment of this mycobacterial disease. Despite being completely curable, tuberculosis is still one of the leading global causes of death. M. tuberculosis, the causative organism – one of the smartest pathogens known – adopts highly intelligent strategies for survival and pathogenesis. Presenting a wealth of information on the molecular infection biology of M. tuberculosis, as well as nontuberculous mycobacteria (NTM), the book provides an overview of the functional role of the PE/PPE group of proteins, which is exclusive to the genus Mycobacteria, of host-pathogen interactions, and virulence. It also explores the pathogenesis of the infection, pathology, epidemiology, and diagnosis of NTM. Finally it discusses current and novel approaches in vaccine development against tuberculosis, including the role of nanotechnology. With state-of-the-art contributions from experts in the respective domains, this book is an informative resource for practitioners as well as medical postgraduate students and researchers. Front Matter ....Pages i-xxii Front Matter ....Pages 1-1 History of TB: Robert Koch and Beyond (Ashfaq Hasan)....Pages 3-16 Tuberculosis as an Underlying Etiological Factor for Other Human Respiratory Diseases (Ronan F. O’Toole)....Pages 17-26 Host Factors in Tuberculosis (Ruxana T. Sadikot)....Pages 27-36 Extrapulmonary Tuberculosis (Surendra K. Sharma, Alladi Mohan)....Pages 37-53 Infections with Nontuberculous Mycobacteria: Increased Awareness and Recent Developments (Astrid Lewin, Hubert Schäfer)....Pages 55-86 Tuberculosis in New Zealand: Historical Overview to Modern Epidemiology (Ronan F. O’Toole)....Pages 87-99 Front Matter ....Pages 101-101 Mycobacterial Methyltransferases: Significance in Pathogenesis and Virulence (Sonam Grover, Rishabh Gangwar, Salma Jamal, Sabeeha Ali, Khairun Nisaa, Nasreen Z. Ehtesham et al.)....Pages 103-122 The PE and PPE Family Proteins of Mycobacterium tuberculosis: What they Are Up To? (Ravi Pal, Faiza Nazar, Sangita Mukhopadhyay)....Pages 123-150 Intrinsically Disordered Regions in PE/PPE Protein Family of Mycobacterium tuberculosis: Moonlighting Function (Farha Naz, Javeed Ahmad, Mohd Shariq, Mohd Arish, Javaid A. Sheikh, Seyed E. Hasnain et al.)....Pages 151-170 Comparative In Silico Analyses Reveal Crucial Factors for Virulence, Antigenicity, and Evolution in M.tb (Yadvir Singh)....Pages 171-188 Importance of Cell Wall-Associated Poly-α-L-Glutamine in the Biology of Pathogenic Mycobacteria (Rajni Garg, Rajesh Mani, Manish Gupta, Deeksha Tripathi, Harish Chandra, Rakesh Bhatnagar et al.)....Pages 189-201 Cellular Stress Responses and Immunological Regulations During Mycobacterium tuberculosis Infection (Nooruddin Khan, Gillipsie Minhas, K. Kala jyothi, Jyoti Sharma)....Pages 203-220 Heat Shock Proteins in the Pathogenesis of Mycobacterium tuberculosis (Prajna Tripathi, Janendra K. Batra)....Pages 221-240 Endoplasmic Reticulum Stress: Importance in Pathogenesis of Mycobacterium tuberculosis (Tarina Sharma, Sonam Grover, Nasreen Z. Ehtesham, Seyed E. Hasnain)....Pages 241-255 Toxin-Antitoxin (TA) Systems in Stress Survival and Pathogenesis (Ashutosh Kumar, Anwar Alam, Pranami Bharadwaj, Sharmistha Tapadar, Mamta Rani, Seyed E. Hasnain)....Pages 257-274 Nucleotide Excision Repair Pathway in Mycobacteria (Manoj Thakur, K. Muniyappa)....Pages 275-300 Mesenchymal Stem Cells: A Hidden Arsenal for Mtb Persistence, Resuscitation, and Reactivation (Jaishree Garhyan, Bikul Das, Rakesh Bhatnagar)....Pages 301-314 Biofilms: A Phenotypic Mechanism of Bacteria Conferring Tolerance Against Stress and Antibiotics (Anwar Alam, Ashutosh Kumar, Prajna Tripathi, Nasreen Z. Ehtesham, Seyed E. Hasnain)....Pages 315-333 Front Matter ....Pages 335-335 Best Practices in Mycobacterial Research Laboratories (Noman Siddiqi)....Pages 337-354 Clinical Aspects and Principles of Management of Tuberculosis (Ashfaq Hasan, Sai Haranath Praveen, Chandrakant Tarke, Fahad Abdullah)....Pages 355-374 Tuberculosis Vaccine: Past Experiences and Future Prospects (Gurpreet Kaur, Deepjyoti K. Das, Sanpreet Singh, Junaid Khan, Mohammad Sajid, Hilal Bashir et al.)....Pages 375-405 Immunotherapeutic Potential of Mycobacterium indicus pranii Against Tuberculosis (Sangeeta Bhaskar, Bindu Singh)....Pages 407-417 TB Diagnostics: Journey from Smear Microscopy to Whole Genome Sequencing (Himanshu Vashistha, K. K. Chopra)....Pages 419-450 Breaking the Transmission of TB: A Roadmap to Bridge the Gaps in Controlling TB in Endemic Settings (Pooja Singh, Jasmine Samal, Sheeba Zarin, Ravikrishnan Elangovan, Seyed E. Hasnain, Nasreen Z. Ehtesham)....Pages 451-461 Challenges and Advances in TB Drug Discovery (Garima Khare, Prachi Nangpal, Anil K. Tyagi)....Pages 463-495 Repurposing of Carbapenems for the Treatment of Drug-Resistant Tuberculosis (Pankaj Kumar, Urvashi B. Singh, Gyanu Lamichhane, Elizabeth Story-Roller)....Pages 497-514

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