Experimental Models of Diabetes

Description

Describes experimental models used in research on diabetes, provides data obtained with those models, and discusses the relative usefulness of models in relation to the diabetic syndrome in humans. Section I examines a widely used model, the streptozotocin (STZ) rat, looking at both the general effe Content: The STZ-Induced Diabetic RatSTZ-Induced Diabetes: Induction, Mechanism(s), and Dose-Dependency, B. Rodrigues, P. Poucheret, M. Battell, and J.H. McNeillAlternations in Myocardial Energy Metabolism in Streptozotocin Diabetes, W. C. Stanley, G.D. Lopaschuk, and K.M. KiviloStructural and Functional Consequences of Streptozotocin-Induced Diabetes on the Kidney, K. Sharma, D.C. Han, A. Mogyorosi, and F.N. ZiyadehPhysiological and Pathological Consequences of STZ-Diabetes on the Heart, B. Rodrigues and J.H. McNeillThe Effects of STZ-Induced Diabetes on the Cytochrome P450 System and Other Metabolic Pathways, C. Ionnides, P.R. Flatt, and C.R. BarnettNerve and Retinal Changes in Experimental Diabetes, S. Chakrabarti Vascular Reactivity in Streptozotocin-Induced Diabetes, R. Subramanian and K.M. MacLeodCardiovascular Function in the Intact, STZ-Treated Rat, R. A. HebdenTreatment and Pharmacological Interventions in STZ -Diabetes, M.L. Battell, B. Rodrigues, V.G. Yuen, and J.H. McNeillOther Experimental Models of DiabetesOther Models of Type I Diabetes, M.L. Battell, V.G. Yuen, S. Verman, and J.H. McNeillSpontaneous Insulin Dependent Diabetes Mellitus (IDDM) in Nonobese Diabetic (NOD) Mice: Comparisons with Experimentally Induced IDDM, E.H. Leiter, I.C. Gerling, and J.C. FlynnThe Neonatal-STZ Model of Diabetes, S.W. Schaffer and M. MozaffariThe BB Rat: A Unique Model of Human Type 1 Diabetes, C.J. Field and S. ButlerNon-Insulin Dependent Animal Models of Diabetes Mellitus, C.H.S. McIntosh and R.A. Pederson