Molecular Targeting and Signal Transduction

Description

Our limited understanding of cellular regulatory signal-transduction-networks has been a barrier to progress in improving the overall cure-rate of human cancers. Delineation of the physiologic roles of the specific regulatory signaling components, with known association with metastatic phenotypes, is a highly promising area which will likely provide the next generation of targeted strategies in the future of molecular cancer medicine. These signaling components are likely to be used in diagnosis, prognosis, and as novel targets for therapeutic development. This book brings together up-to-date summaries by leading cancer researchers on the major principles of cancer cell biology: survival, apoptosis, adhesion, and cell cycle deregulation. It is directed at clinicians and scientists working in the areas of experimental and molecular therapeutics, molecular medicine, translational cancer research, and bio-medical sciences in general. Biology of the Epidermal Growth Factor Receptor Family....Pages 1-13 Integrin Signaling in Cancer....Pages 15-31 Regulators of Vascular Endothelial Growth Factor Expression in Cancer....Pages 33-58 Integrin-Linked Kinase (ILK) in Combination Molecular Targeting....Pages 59-75 P21-Activated Kinase 1: An Emerging Therapeutic Target....Pages 77-88 Basis and Importance of SRC as a Target in Cancer....Pages 89-119 Therapeutic Targeting of the Receptor Tyrosine Kinase Met....Pages 121-138 Nuclear Factor-κB Activation Mediates Cellular Transformation, Proliferation, Invasion Angiogenesis and Metastasis of Cancer....Pages 139-173 The P53 Pathway: Targets for the Development of Novel Cancer Therapeutics....Pages 175-181 Runx Protein Signaling in Human Cancers....Pages 189-215 Signal Transduction Mediated by Cyclin D1: from Mitogens to Cell Proliferation: A Molecular Target with Therapeutic Potential....Pages 217-237 Signal Transduction Pathways in BCR-ABL Transformed Cells....Pages 239-270 Estrogen Receptors and Anti-Estrogen Therapies....Pages 271-292 Targeting Endothelin Axis in Cancer....Pages 293-314 km23: A Novel TGFβ Signaling Target Altered in Ovarian Cancer....Pages 315-327