Essentials of Bioinformatics, Volume I: Understanding Bioinformatics: Genes to Proteins

Description

Bioinformatics is an integrative field of computer science, genetics, genomics, proteomics, and statistics, which has undoubtedly revolutionized the study of biology and medicine in past decades. It mainly assists in modeling, predicting and interpreting large multidimensional biological data by utilizing advanced computational methods. Despite its enormous potential, bioinformatics is not widely integrated into the academic curriculum as most life science students and researchers are still not equipped with the necessary knowledge to take advantage of this powerful tool. Hence, the primary purpose of our book is to supplement this unmet need by providing an easily accessible platform for students and researchers starting their career in life sciences. This book aims to avoid sophisticated computational algorithms and programming. Instead, it mostly focuses on simple DIY analysis and interpretation of biological data with personal computers. Our belief is that once the beginners acquire these basic skillsets, they will be able to handle most of the bioinformatics tools for their research work and to better understand their experimental outcomes. Unlike other bioinformatics books which are mostly theoretical, this book provides practical examples for the readers on state-of-the-art open source tools to solve biological problems. Flow charts of experiments, graphical illustrations, and mock data are included for quick reference. Volume I is therefore an ideal companion for students and early stage professionals wishing to master this blooming field. Front Matter ....Pages i-xiv Introduction to Bioinformatics (Babajan Banaganapalli, Noor Ahmad Shaik)....Pages 1-18 Introduction to Biological Databases (Noor Ahmad Shaik, Ramu Elango, Muhummadh Khan, Babajan Banaganapalli)....Pages 19-27 Sequence Databases (Vivek Kumar Chaturvedi, Divya Mishra, Aprajita Tiwari, V. P. Snijesh, Noor Ahmad Shaik, M. P. Singh)....Pages 29-46 Biological 3D Structural Databases (Yasser Gaber, Boshra Rashad, Eman Fathy)....Pages 47-73 Other Biological Databases (Divya Mishra, Vivek Kumar Chaturvedi, V. P. Snijesh, Noor Ahmad Shaik, M. P. Singh)....Pages 75-96 Introduction to Nucleic Acid Sequencing (Preetha J. Shetty, Francis Amirtharaj, Noor Ahmad Shaik)....Pages 97-126 Tools and Methods in the Analysis of Simple Sequences (Yogesh Kumar, Om Prakash, Priyanka Kumari)....Pages 127-153 Tools and Methods in Analysis of Complex Sequences (Noor Ahmad Shaik, Babajan Banaganapalli, Ramu Elango, Jumana Y. Al-Aama)....Pages 155-167 Structural Bioinformatics (Bhumi Patel, Vijai Singh, Dhaval Patel)....Pages 169-199 Protein Structure Annotations (Mirko Torrisi, Gianluca Pollastri)....Pages 201-234 Introduction to Functional Bioinformatics (Peter Natesan Pushparaj)....Pages 235-254 Biological Networks: Tools, Methods, and Analysis (Basharat Ahmad Bhat, Garima Singh, Rinku Sharma, Mifftha Yaseen, Nazir Ahmad Ganai)....Pages 255-286 Metabolomics (Peter Natesan Pushparaj)....Pages 287-318 Drug Discovery: Concepts and Approaches (Varalakshmi Devi Kothamuni Reddy, Babajan Banaganapalli, Galla Rajitha)....Pages 319-334 Molecular Docking (Babajan Banaganapalli, Fatima A. Morad, Muhammadh Khan, Chitta Suresh Kumar, Ramu Elango, Zuhier Awan et al.)....Pages 335-353 In Silico PCR (Babajan Banaganapalli, Noor Ahmad Shaik, Omran M. Rashidi, Bassam Jamalalail, Rawabi Bahattab, Hifaa A. Bokhari et al.)....Pages 355-371 Modeling and Optimization of Molecular Biosystems to Generate Predictive Models (Ankush Bansal, Siddhant Kalra, Babajan Banaganapalli, Tiratha Raj Singh)....Pages 373-387 Back Matter ....Pages 389-405