ENGLISH

Immunosuppressant Analogs in Neuroprotection

By Paul R. Sanberg , Cesario V. Borlongan , Ole Isacson

Book information

Year
2002
ISBN
0896039447, 9780896039445, 9781592593156
LCC
RC365 .I46 2003
Open Library ID
OL19062611M
Language
english
Format
PDF
Filesize
7 MB (7016488 bytes)
Edition
1st
Pages
416\408
Topic
Medicine immunology
Time added
2011-06-04 13:46:07

Description

An authoritative survey of the most recent scientific evidence showing how cyclosporin, FK-506, and their analogs-the neuroimmunophilins-evolved from being purely immunosuppressant "drugs" to neuroprotective "agents". The book focuses on recent preclinical evidence that demonstrates the neurotrophic/neuroprotective effects of immunosuppressants when administered alone or when combined with neural transplantation therapy in animal models of neurological disorders. It also discusses their efficacy and mechanisms of action in vitro and in vivo models of CNS disease, and provides laboratory studies with compelling clinical indications for Alzheimer's disease, Huntington's disease, stroke, traumatic brain injury, spinal cord injury, ALS, sciatic nerve injury, and drug addiction.

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