ENGLISH

The pathogenesis of neurodegenerative disorders

By Mark P. Mattson

Book information

Publisher
Humana Press
Year
2001
ISBN
9780896038387, 0-89603-838-6
Open Library ID
OL9473978M
Language
english
Format
PDF
Filesize
5 MB (5534868 bytes)
Series
Contemporary neuroscience
Edition
1
Pages
306\306
Topic
Medicine Neurology
Library
mexmat
Time added
2009-07-20 03:45:11

Description

In this groundbreaking book, leading experts detail the cellular and molecular cascades that cause selective degeneration of neuronal populations, and illuminate those genetic and environmental factors that are critical to the facilitation or suppression of the neuropathologic processes. Working from studies of human patients, as well as from cell culture and animal models, the authors demonstrate a heretofore unrecognized convergence of the causative pathogenetic mechanisms for clinically distinct neurological disorders. At center stage are the biochemical and molecular cascades that will ultimately lead to neuronal death-cascades involving oxyradical production, aberrant regulation of cellular ion homeostasis, activation of specific proteases, and activation of a stereotyped sequence of events involving mitochondial dysfunction. Individual chapters examine how these mechanisms-along with genetic and environmental factors-operate in Alzheimer's and Parkinson's diseases, Down's syndrome, amyotropic lateral sclerosis, ischemic stroke, spinal cord injury, and Duchenne muscular dystrophy.

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