Molecular Mechanisms of Nutritional Interventions and Supplements for the Management of Sexual Dysfunction and Benign Prostatic Hyperplasia

Description

Molecular Mechanisms of Nutritional Interventions and Supplements for the Management of Sexual Disfunction and Benign Prostatic Hyperplasia presents the epidemiologic data linking diet with BPH and ED, along with a deep explanation on why nutritional approaches and different macronutrients may modify the pathogenesis of the disease. Coverage includes the relevance/epidemiology of the disease, pathophysiological events causing the disease, available therapeutic options, molecular mechanisms of action of available treatments, epidemiological and intervention studies suggesting the benefit of diet as therapeutic option for BPH and ED, and potential mechanisms of action of nutritional based approaches as treatment for BPH and ED. By combining medicine, diet and lifestyle options, this title provides a truly multidisciplinary approach to BPH and ED, making it a unique resource for those treating BPH and an irreplaceable reference guide for those in research. Front Cover Molecular Mechanisms of Nutritional Interventions and Supplements for the Management of Sexual Dysfunction and Benign Prost... Copyright Page Contents List of contributors 1 Introduction to benign prostatic hyperplasia Introduction and epidemiology Risk factors Pathophysiology of BPH Diagnosis and workup Management of BPH Overview of current literature addressing the association between diet and BPH Conclusion References Further reading 2 Introduction to erectile dysfunction Introduction Epidemiology Modifiable risk factors Cardiovascular disease Diabetes mellitus Depression and anxiety Other modifiable risk factors Lower urinary tract symptoms Nonmodifiable risk factors Age Race and socioeconomic status Pathophysiology of ED Physiology of initiating, maintaining, and terminating an erection Pathophysiology of ED Vasculogenic: arteriogenic Vasculogenic: cavernosal Neurogenic Anatomic Endocrinologic Psychogenic Pharmacologic Workup of ED Current treatment options for ED Highlights and take-home messages References 3 Diet as a risk factor and intervention for lower urinary tract symptoms secondary to benign prostatic hyperplasia Introduction Relationship of inflammation to LUTS/BPH Hypogonadism and LUTS/BPH Metabolic syndrome and LUTS/BPH Metabolic syndrome and diet Relationship of exercise to LUTS/BPH Influence of fluid type and volume to LUTS/BPH Influence of food type to LUTS/BPH Grain/starch Fruits and vegetables Dairy Protein Zinc Conclusion References 4 Effects of metabolic syndrome on benign prostatic hyperplasia Overview of metabolic syndrome Metabolic syndrome and BPH Hyperglycemia and BPH Obesity and BPH Association of hypercholesterolemia and hypertriglyceridemia with BPH Hypertension and BPH Highlights and take-home messages References Further reading 5 Effects of metabolic syndrome on erectile dysfunction Review of established associations between metabolic syndrome and erectile dysfunction Hyperglycemia and ED Obesity and ED Hypertension and ED Association of hypercholesterolemia and hypertriglyceridemia with ED Highlights and take-home messages References Further reading 6 Role of diet in the development and progression of benign prostatic hyperplasia Current understanding of the pathophysiology Risk factors Modifiable Nonmodifiable Epidemiologic studies on diet and BPH Overview Role of fat intake Role of protein intake Carbohydrate and grain consumption Red meat consumption Dairy consumption Vegetable consumption Fruit consumption Alcohol consumption Consumption of assorted other foods Diet management overview/summary for BPH Interventional studies Moderating fiber/fat intake Zinc Flaxseed Fluted pumpkin/Telfairia occidentalis Highlights and take-home messages References 7 Role of diet in the development and progression of erectile dysfunction Erectile dysfunction: A modifiable disease Risk factors for erectile dysfunction Dietary risk factors Tobacco use Cardiovascular disease Review of the current understanding of diet management in erectile dysfunction Mediterranean diet Role of fat intake Role of calories Role of protein intake Role of sodium intake Role of fiber intake Red meat consumption Soy consumption Nut consumption Fruits and vegetables consumption Alcohol consumption Diet management overview Highlights and take-home messages References 8 Nutritional supplementation for benign prostatic hyperplasia Serenoa repens (saw palmetto) β-Sitosterol Pygeum africanum Cernilton Lycopene Vitamin D Pomegranate Zinc Summary/conclusion References 9 Nutritional supplements and erectile dysfunction Introduction L-Arginine L-Citrulline Yohimbine Maca Korean red ginseng Vitamin D Dehydroepiandrosterone Icariin (isolated from horny goat weed or Epimedium) Niacin Pomegranate Saffron Conclusion References 10 Eastern diet and benign prostatic hyperplasia Diet and pathophysiology of benign prostatic hyperplasia Vegetables Mechanism of action Fish Mechanism of action Tomatoes Mechanism of action Soy Mechanism of action Conclusion References 11 Eastern diet and erectile dysfunction Diet and pathophysiology of erectile dysfunction Panax ginseng ED, somatic symptoms, and ginseng Mechanism of ginseng on improving symptoms of ED Ginseng and vasculogenic ED Ginseng and psychogenic ED Curry powder Chilies Vegetables Homocysteine and ED Folate and psychogenic ED Conclusion References Further reading 12 Western diet and benign prostatic hyperplasia Introduction Prevalence of BPH Link between Western diet and BPH Carbohydrates Protein Cholesterol Vegetables and fruits Vitamins and minerals Vitamin A Vitamin C Vitamin D Vitamin E Zinc Future perspectives on nutritional management of BPH Conclusion References Further reading 13 Western diet and erectile dysfunction Introduction Relationship between the Western diet and erectile dysfunction Erectile dysfunction and cardiovascular disease Erectile dysfunction and obesity Erectile dysfunction and metabolic syndrome Dietary components and erectile dysfunction Carbohydrates Fatty acids and cholesterol Dietary modifications for erectile dysfunction Conclusion References Further reading 14 Effect of diet on storage symptoms in male lower urinary tract symptoms Introduction Fluid management Caffeine Carbonated beverages Artificially sweetened beverages Citrus and vitamin C Alcohol Milk Conclusion References 15 Effects of exercise on benign prostatic hyperplasia, lower urinary tract symptoms, and erectile dysfunction Introduction Metabolic syndrome and exercise Types of exercise Components of metabolic syndrome Exercise and metabolic syndrome Physical activity and BPH/LUTS Overview of BPH and LUTS Effects of exercise on BPH and LUTS Proposed mechanisms for improvements in BPH with exercise Growth of prostate epithelial cells Exercise-induced changes in gene expression Changes in hormone expression Patient education and recommendations Physical activity and ED Review of risk factors Pathophysiology of abnormal endothelial function in men with ED Endothelial function Obesity as a state of chronic inflammation Effect of physical activity on testosterone levels Effects of physical activity alone Effects of physical activity in combination with PDE-5 inhibitors Patient education and recommendations Other nonpharmacologic lifestyle interventions Conclusion References 16 Conclusions and recommendations References Index Back Cover