Channelopathies in Heart Disease

Description

This book provides an expert overview on ion channel-related arrhythmia mechanisms, and describes important advances in our understanding of how ion channel dysfunction causes cardiac disease. Both, scientific findings and clinical implications are presented and discussed by scientists who have considerably contributed to the field. The book is organized in three parts: part I treats the molecular and electrophysiological mechanisms of function and dysfunction of ion channels, part II focuses on genetics and clinical findings, whereas part III describes novel research techniques, the use of stem cells and animal models and provides an outlook on future investigations and applications. The book is written for scientists in Cardiovascular Biology and Neuroscience and will be of general interest to Medical Doctors in Cardiology, Cardiac Electrophysiology and related disciplines. Front Matter ....Pages i-vi Channelopathies in Heart Disease (Carol Ann Remme, Dierk Thomas)....Pages 1-5 Front Matter ....Pages 7-7 Cardiac Sodium Channel (Dys)Function and Inherited Arrhythmia Syndromes (Carol Ann Remme)....Pages 9-45 Potassium Channels in the Heart (Morten B. Thomsen)....Pages 47-75 Voltage-Gated Calcium Channels and Their Roles in Cardiac Electrophysiology (Jordi Heijman, Cristina E. Molina, Niels Voigt)....Pages 77-96 HCN Channels and Cardiac Pacemaking (Annalisa Bucchi, Chiara Piantoni, Andrea Barbuti, Dario DiFrancesco, Mirko Baruscotti)....Pages 97-126 Dysregulation of Ionic Homeostasis: Relevance for Cardiac Arrhythmias (Claire Hopton, Luigi Venetucci, Miriam Lettieri)....Pages 127-144 Front Matter ....Pages 145-145 Long and Short QT Syndromes (Lia Crotti, Maria-Christina Kotta, Silvia Castelletti)....Pages 147-185 Brugada Syndrome: Current Perspectives (Apichai Khongphatthanayothin, Koonlawee Nademanee)....Pages 187-214 Sinus Node Disease and Cardiac Conduction Disease (Patrick A. Schweizer)....Pages 215-229 Catecholaminergic Polymorphic Ventricular Tachycardia (Riccardo Maragna, Carlo Napolitano)....Pages 231-256 Idiopathic Ventricular Fibrillation and Early Repolarization (Pieter G. Postema)....Pages 257-275 Atrial Fibrillation (Ann-Kathrin Rahm, Hugo A. Katus, Dierk Thomas)....Pages 277-322 Genetic Testing for Inheritable Cardiac Channelopathies (Florence Kyndt, Jean-Baptiste Gourraud, Julien Barc)....Pages 323-358 Front Matter ....Pages 359-359 Novel Imaging Techniques in Cardiac Ion Channel Research (Esperanza Agullo-Pascual, Alejandra Leo-Macias, Donna R. Whelan, Mario Delmar, Eli Rothenberg)....Pages 361-378 Transgenic Animal Models of Cardiac Channelopathies: Benefits and Limitations (Katja E. Odening, David Ziupa)....Pages 379-420 Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Towards Personalized Therapeutic Strategies? (Daniel Sinnecker, Alessandra Moretti)....Pages 421-437