Bio/CMOS Interfaces and Co-Design

Description

The application of CMOS circuits and ASIC VLSI systems to problems in medicine and system biology has led to the emergence of Bio/CMOS Interfaces and Co-Design as an exciting and rapidly growing area of research. The mutual inter-relationships between VLSI-CMOS design and the biophysics of molecules interfacing with silicon and/or onto metals has led to the emergence of the interdisciplinary engineering approach to Bio/CMOS interfaces. This new approach, facilitated by 3D circuit design and nanotechnology, has resulted in new concepts and applications for VLSI systems in the bio-world. This book offers an invaluable reference to the state-of-the-art in Bio/CMOS interfaces. It describes leading-edge research in the field of CMOS design and VLSI development for applications requiring integration of biological molecules onto the chip. It provides multidisciplinary content ranging from biochemistry to CMOS design in order to address Bio/CMOS interface co-design in bio-sensing applications. Front Matter....Pages i-xiv Introduction....Pages 1-12 Chemistry of Conductive Solutions....Pages 13-28 Biochemistry of Targets and Probes....Pages 29-51 Target/Probe Interactions....Pages 53-85 Surface Immobilization of Probes....Pages 87-116 Nanotechnology to Prevent Electron Transfer....Pages 117-134 Bio/CMOS Interfaces for Label-Free Capacitance Sensing....Pages 135-155 Nanotechnology to Enhance Electron Transfer....Pages 157-183 Bio/CMOS Interfaces in Constant Bias....Pages 185-205 Bio/CMOS Interfaces in Voltage Scan....Pages 207-224 Back Matter....Pages 225-258