ENGLISH

Actin Polymerization in Apicomplexan: A Structural, Functional and Evolutionary Analysis

By Avinash Kale

Book information

Publisher
Springer Singapore
Year
2019
ISBN
978-981-13-7449-4, 978-981-13-7450-0
Language
english
Format
PDF
Filesize
3 MB (2818310 bytes)
Edition
1st ed. 2019
Pages
XI, 101\107
Time added
2020-02-08 04:42:59
Biomedicine; Parasitology; Biomechanics; Protein S

Description

This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements. The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPα and CPβ), cyclase-associated protein (CAP) and coronin 13–24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design. Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics. Front Matter ....Pages i-xi Actin Polymerization: A Cellular Perspective for Motility (Samridhi Pathak, Sarita Tripathi, Ricka Gauba, Sarath Chandra Dantu, Avinash Kale)....Pages 1-14 Actin: The Central Ubiquitous Player in the Phenomenon (Samridhi Pathak, Ricka Gauba, Sarath Chandra Dantu, Avinash Kale)....Pages 15-28 Formin: The Multidomain Elongator of Actin Polymer (Samridhi Pathak, Ricka Gauba, Sarath Chandra Dantu, Dhriti Sheth, Avinash Kale)....Pages 29-38 Profilin: The Associates of Formin (Samridhi Pathak, Ricka Gauba, Sarath Chandra Dantu, Avinash Kale)....Pages 39-50 ADF (Actin Depolymerizing Factor): The Breaker of the Polymer in Homeostasis (Samridhi Pathak, Ricka Gauba, Sarath Chandra Dantu, Avinash Kale)....Pages 51-62 CAP (Cyclase-Associated Protein): The Silent Worker (Samridhi Pathak, Ricka Gauba, Sarath Chandra Dantu, Avinash Kale)....Pages 63-68 Capping Protein (CP): The Formin Competitor (Samridhi Pathak, Ricka Gauba, Sarath Chandra Dantu, Avinash Kale)....Pages 69-75 Coronin: An Overview (Samridhi Pathak, Ricka Gauba, Sarath Chandra Dantu, Avinash Kale)....Pages 77-83 Evolution: The Hallmarks of Gliding Motility in Apicomplexan (Samridhi Pathak, Ricka Gauba, Sarath Chandra Dantu, Avinash Kale)....Pages 85-91 Actin Polymerization in Apicomplexans: A Novel Perspective (Samridhi Pathak, Ricka Gauba, Avinash Kale)....Pages 93-97 Back Matter ....Pages 99-101

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