Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions

Description

Genomic and Epigenomic Biomarkers of Toxicology and Disease The latest developments in biomarker research applicable to toxicology and medicine Research on genomic and epigenomic biomarkers is developing rapidly with cutting-edge studies scattered throughout the academic literature, making the status of ongoing scientific activity in this area difficult to ascertain. Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions delivers a comprehensive and authoritative compilation of up-to-date developments in the application of genomic and epigenomic biomarkers to toxicology, disease prevention, cancer detection, therapeutics, gene therapy, and other areas. With contributions from a collection of internationally recognized investigators, this edited volume offers unique insights into current trends and future directions of research in the discussed areas. Combining state-of-the-art information on genomic and epigenomic biomarkers from a range of specialists from around the world, this monograph includes: A thorough introduction to microRNAs as non-invasive biomarkers of toxicity and chemical hazardComprehensive explorations of extracellular vesicle-associated miRNAs as toxic biomarkers, as well as transcriptomic applications in toxicology and medicinePractical discussions of circulating miRNAs as biomarkers of metal exposure, as well as microRNAs biomarkers of malignant mesotheliomaIn-depth examinations of the role of noncoding RNAs in innate immune responses perturbed by environmental arsenic with a focus on microRNAs Perfect for researchers, toxicologists, risk assessors, and regulators, Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions will also earn a place in the libraries of graduate students with an interest in biomarkers, toxicology, agriculture, or the environment. Genomic and Epigenomic Biomarkers of Toxicology and Disease Contents Dedication Preface Acknowledgements List of Contributors 1 Genomic and Epigenomic Biomarkers for Predictive Toxicity and Disease 2 MicroRNAs as Non-invasive Biomarkers of Toxicity and Chemical Hazard: Genomic and Epigenomic Biomarkers of Toxicology and Disease 3 EV (Extracellular Vesicle)-associated miRNAs as Biomarkers of Toxicity 4 Circulating miRNAs as Biomarkers of Toxic Heavy Metal Exposure 5 MicroRNA Biomarkers of Malignant Mesothelioma 6 Role of Non-coding RNAs in Innate Immune Responses Perturbed by Environmental Arsenic Exposure 7 Transcriptomics: Applications in Toxicology and Medicine 8 Network Biology for Biomarker Discovery and Therapy in Cancer 9 Epigenetic Biomarkers: Link to Maternal Exposure and Offspring Health Outcomes 10 The Role of Dynamic Epigenetic Changes in Modulating Homeostasis after Exposure to Low-dose Environmental Chemicals 11 Emerging Non-invasive Molecular Biomarkers for Early Cancer Detection 12 Aberrant DNA Methylation of Tumor Suppressor Genes and Oncogenes as Cancer Biomarkers 13 SMYD Protein Family as Promising Biomarkers for Cancer Diagnosis and Prognosis 14 Toward Precision Medicine: Epigenetic Alterations in Human Melanoma 15 Currents Trends and Future Perspectives in Our Epigenetic Signatures: What a Diet Can Trigger 16 Genetic and Epigenetic Biomarkers of Organophosphate Compounds, Dialkyl Phosphate Exposure, and Their Relation to Biological Effects 17 Genetic, Epigenetic, and Anatomical Factors in Agenesis and Development of Female Reproductive Tract 18 Cause or Consequence: Epigenomic DNA Methylation Changes in Arsenic- Mediated in Vitro Transformation of Human Prostate Cells 19 Epigenetic Regulation of Sex Determination and Toxicity in Nonmammalian Vertebrates 20 Characterization of Genomic and Epigenomic Biomarkers of Nanoparticle Toxicity Using the Zebrafish Model System Index EULA