ENGLISH

CXCR3

By Farber J.M. , Moser B.

Book information

DOI
10.1006/rwcy.2000.21003
Language
english
Format
PDF
Filesize
148 kB (151059 bytes)
Pages
6\6
Library
mexmat
Time added
2009-07-20 03:45:11

Description

CXCR3 is a seven transmembrane domain G protein-coupled receptor for the interferon-inducible CXC chemokines IP-10, MIG, and I-TAC. CXCR3 is expressed on T cells, B cells, and NK cells. Receptor expression and function on T cells are induced dramatically by T cell activation, and CXCR3 has been reported to be expressed preferentially on TH1 cell lines and clones. CXCR3 has been found on T cells in a variety of human inflammatory lesions including rheumatoid arthritis and multiple sclerosis and it is presumed that CXCR3 is involved in the recruitment of activated T cells to inflammatory sites.

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