ENGLISH

Breast Cancer Chemosensitivity

By Ana Maria Gonzalez-Angulo , Flavia Morales-Vasquez (auth.) , Dihua Yu , Mien-Chie Hung (eds.)

Book information

Publisher
Springer-Verlag New York
Year
2007
ISBN
9780387740379, 0387740376
DOI
10.1007/978-0-387-74039-3
LCC
RC280.B8 B6658 2007
Open Library ID
OL14762811M
Language
english
Format
PDF
Filesize
5 MB (4863712 bytes)
Series
Advances in Experimental Medicine and Biology 608
Edition
1
Pages
175\188
Scanned
yes
Time added
2011-06-04 13:46:07
Cancer Research; Biochemistrygeneral; Molecular Medicine; Cell Biology

Description

In Breast Cancer Chemosensitivity, a group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem Breast Cancer Chemosensitivity moves on to focus on the latest findings of molecular mechanisms of drug resistance. These include in-depth discussions on multidrug resistance by P-glycoprotein and the multidrug resistance protein family, resistance to therapeutic agent-induced apoptosis, cell cycle deregulation, deregulation of DNA repair, loss of tumor suppressor genes, integrin-mediated adhesion, insulin-like growth factors, epidermal growth factor, and ErbB2 in modulating breast cancer response to systemic therapy, especially, certain chemotherapeutic agents. Breast Cancer Chemosensitivity provides an example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment.

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