Janeway's Immunobiology

Description

Cover Title Page Publisher’s Notice Copyright Preface What’s New in the Tenth Edition Resources for Instructors and Students Acknowledgments About the Authors Contents in Brief Detailed Contents Chapter 1: Basic Concepts in Immunology The origins of vertebrate immune cells. Principles of innate immunity. Principles of adaptive immunity. The effector mechanisms of immunity. References Chapter 2: Innate Immunity: The First Lines of Defense Anatomic barriers and initial chemical defenses. The complement system and innate immunity. End of Chapter Questions and References Chapter 3: Cellular Mechanisms of Innate Immunity Pathogen recognition by cells of the innate immune system. Consequences of innate immune activation. End of Chapter Questions and References Chapter 4: Antigen Recognition by B-cell and T-cell Receptors The structure of a typical antibody molecule. Structural variation in immunoglobulin constant regions. The interaction of the antibody molecule with specific antigen. Antigen recognition by T cells. End of Chapter Questions and References Chapter 5: The Generation of Lymphocyte Antigen Receptors Primary immunoglobulin gene rearrangements and expression. T-cell receptor gene rearrangement. Evolution of the adaptive immune response. End of Chapter Questions and References Chapter 6: Antigen Presentation to T Lymphocytes The generation of αβ T-cell receptor ligands. The major histocompatibility complex and its function. Recognition of nonpeptide ligands by unconventional T-cell subsets. End of Chapter Questions and References Chapter 7: Lymphocyte Receptor Signaling General principles of signal transduction and propagation. Antigen receptor signaling and lymphocyte activation. Co-stimulatory and inhibitory receptors modulate antigen receptor signaling in T and B lymphocytes. End of Chapter Questions and References Chapter 8: The Development of B and T Lymphocytes Development of B lymphocytes. Development of T lymphocytes. Positive and negative selection of T cells. End of Chapter Questions and References Chapter 9: T Cell–Mediated Immunity Development and function of secondary lymphoid organs–sites for the initiation of adaptive immune responses. Naive T-cell activation, clonal expansion, and differentiation into effector and memory T cells. General properties of effector T cells and their cytokines. T cell–mediated cytotoxicity. End of Chapter Questions and References Chapter 10: The Humoral Immune Response B-cell activation by antigen and helper T cells. The distributions and functions of immunoglobulin classes. The destruction of antibody-coated pathogens via Fc receptors. End of Chapter Questions and References Chapter 11: Integrated Dynamics of Innate and Adaptive Immunity Integration of innate and adaptive immunity in response to specific types of pathogens. Effector CD4 T cells augment the effector functions of innate immune cells. Immunological memory. End of Chapter Questions and References Chapter 12: The Barrier Immune System Organization of the mucosal immune system. Innate immune defenses of the intestinal immune system. The role of adaptive immunity in regulating the intestinal mucosal immune system at homeostasis. The intestinal immune response in host defense and immune-mediated disease. Immunity at other barrier tissues. End of Chapter Questions and References Chapter 13: Failures of Host Defense Mechanisms Immunodeficiency diseases. Evasion and subversion of immune defenses. Acquired immune deficiency syndrome. End of Chapter Questions and References Chapter 14: Allergic Diseases and Hypersensitivity Reactions IgE and IgE-mediated allergic diseases. Effector mechanisms in IgE-mediated allergic reactions. Non-IgE-mediated allergic diseases. End of Chapter Questions and References Chapter 15: Autoimmunity and Transplantation The making and breaking of self-tolerance. Autoimmune diseases and pathogenic mechanisms. The genetic and environmental basis of autoimmunity. Responses to alloantigens and transplant rejection. End of Chapter Questions and References Chapter 16: Manipulation of the Immune Response Fighting infectious diseases with vaccination. Using the immune response to attack tumors. Treatment of unwanted immune responses. End of Chapter Questions and References Appendix I: The Immunologist’s Toolbox Appendix II: CD Antigens Appendix III: Cytokines and Their Receptors Appendix IV: Chemokines and Their Receptors Glossary Credits Index Movies and Animations Endpaper