ENGLISH

Sickle Cell Anemia: From Basic Science to Clinical Practice

By Fernando Ferreira Costa , Nicola Conran (eds.)

Book information

Publisher
Springer International Publishing
Year
2016
ISBN
978-3-319-06712-4, 978-3-319-06713-1
DOI
10.1007/978-3-319-06713-1
Language
english
Format
PDF
Filesize
10 MB (10504981 bytes)
Edition
1
Pages
XV, 435\439
Time added
2016-07-20 04:00:00
generalHematology; Internal Medicine; Medical Biochemistr

Description

Although sickle cell anemia was the first molecular disease to be identified, its complex and fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin gene incurs numerous molecular and cellular mechanisms that contribute to the plethora of symptoms associated with the disease. Our knowledge regarding sickle cell disease mechanisms, while still not complete, has broadened considerably over the last decades. Sickle Cell Anemia: From Basic Science to Clinical Practice aims to provide an update on our current understanding of the disease’s pathophysiology and use this information as a basis to discuss its manifestations in childhood and adulthood. Current therapies and prospects for the development of new approaches for the management of the disease are also covered.

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