ENGLISH

Gamma-Glutamyl Transpeptidases: Structure and Function

By Immacolata Castellano , Antonello Merlino (auth.)

Book information

Publisher
Springer Basel
Year
2013
ISBN
9783034806817, 9783034806824
Language
english
Format
PDF
Filesize
5 MB (4923029 bytes)
Series
SpringerBriefs in Biochemistry and Molecular Biology
Edition
1
Pages
57\65
Time added
2020-08-30 06:11:09
Enzymology; Human Physiology; Biochemical Engineer

Description

Gamma-Glutamyl Transpeptidases (γ-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the γ-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released γ-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). γ-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.γ-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson’s disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers current knowledge about the structure-function relationship of γ-GTs and gives information about applications of γ-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine.​ Front Matter....Pages i-viii Gamma-Glutamyl Transpeptidases: Structure and Function....Pages 1-57

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