Autophagy: Biology and Diseases: Basic Science

Description

This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 1 focuses on the biology of autophagy, including the signaling pathways, regulating processes and biological functions. Autophagy is a fundamental physiological process in eukaryotic cells. It not only regulates normal cellular homeostasis, and organ development and function, but also plays an important role in the pathogenesis of a wide range of human diseases. Thanks to the rapid development of molecular biology and omic technologies, research on autophagy has boomed in recent decades, and more and more cellular and animal models and state-of the-art technologies are being used to shed light on the complexity of signaling networks involved in the autophagic process. Further, its involvement in biological functions and the pathogenesis of various diseases has attracted increased attention around the globe. Presenting cutting-edge knowledge, this book series is a useful reference resource for researchers and clinicians who are working on or interested in autophagy. Front Matter ....Pages i-xv Front Matter ....Pages 1-1 History and Current Status of Autophagy Research (Rui Sheng, Zheng-Hong Qin)....Pages 3-37 Front Matter ....Pages 39-39 Regulation of ATG and Autophagy Initiation (Wen Li, Lining Zhang)....Pages 41-65 Regulation of Autophagy by mTOR Signaling Pathway (Ying Wang, Hongbing Zhang)....Pages 67-83 AMPK and Autophagy (Yanjun Li, Yingyu Chen)....Pages 85-108 Beclin 1, Bcl-2 and Autophagy (Hai-Dong Xu, Zheng-Hong Qin)....Pages 109-126 TP53, TP53 Target Genes (DRAM, TIGAR), and Autophagy (Wanglai Hu, Song Chen, Rick F. Thorne, Mian Wu)....Pages 127-149 Ca(2+) Ion and Autophagy (Yang-Xi Hu, Xiao-Shuai Han, Qing Jing)....Pages 151-166 Endoplasmic Reticulum Stress and Autophagy (Zhihao Qi, Linxi Chen)....Pages 167-177 Oxidative Stress and Autophagy (Qi Gao)....Pages 179-198 Non-coding RNAs and Autophagy (Honghong Yao, Bing Han, Yuan Zhang, Ling Shen, Rongrong Huang)....Pages 199-220 Epigenetic Regulation of Autophagy (Li-Fang Hu)....Pages 221-236 Protein Modification and Autophagy Activation (Rui Wang, Guanghui Wang)....Pages 237-259 Other Molecular Mechanisms Regulating Autophagy (Nan Zhang, Ying Zhao)....Pages 261-271 The Role of Nanomaterials in Autophagy (Min Wei, Wei-Dong Le)....Pages 273-286 Structural Basis of Autophagy Regulatory Proteins (Lifeng Pan, Jianping Liu, Ying Li)....Pages 287-326 Front Matter ....Pages 327-327 Autophagy and Energy Metabolism (Jie Yang, Ruimin Zhou, Zhenyi Ma)....Pages 329-357 Autophagy and Lipid Metabolism (Muhammad Babar Khawar, Hui Gao, Wei Li)....Pages 359-374 Autophagy and the Metabolism of Misfolding Protein (Chao Cheng, Zhen-Guo Liu)....Pages 375-420 Autophagy in Mitochondrial Quality Control (Rui Wang, Guanghui Wang)....Pages 421-434 Chaperone-Mediated Autophagy (Qian Yang, Ronglin Wang, Lin Zhu)....Pages 435-452 Autophagy in Reproduction (Hui Gao, Muhammad Babar Khawar, Wei Li)....Pages 453-468 Autophagy in Development and Differentiation (Yang-Xi Hu, Xiao-Shuai Han, Qing Jing)....Pages 469-487 Autophagy in Normal Stem Cells and Specialized Cells (Kun Liu, Liang Wang, Tongbiao Zhao)....Pages 489-508 Autophagy, Aging, and Longevity (Li Luo, Zheng-Hong Qin)....Pages 509-525 Autophagy and Ubiquitin-Proteasome System (Yan Wang, Wei-Dong Le)....Pages 527-550 Immune Signaling and Autophagy Regulation (Fang Hua, Ke Li, Shuang Shang, Feng Wang, Zhuowei Hu)....Pages 551-593 Autophagy and the Immune Response (Bing Cui, Heng Lin, Jinmei Yu, Jiaojiao Yu, Zhuowei Hu)....Pages 595-634 Autophagy and Immune Tolerance (Yao-Xing Wu, Shou-Heng Jin, Jun Cui)....Pages 635-665 Autophagy—Cell Survival and Death (Xiaojie Yan, Ruimin Zhou, Zhenyi Ma)....Pages 667-696 Coordination of Autophagy and Other Cellular Activities (Hui-Ling Zhang, Yong-Ming Zhu, Xian-Yong Zhou)....Pages 697-727