ENGLISH

Radiopharmaceuticals : a guide to PET/CT and PET/MRI

By Orazio Schillaci (editor); Ferdinando Calabria (editor)

Book information

Publisher
Springer
Year
2020
ISBN
9783030277789, 303027778X, 9783030277796, 3030277798, 9783030277802, 3030277801, 9783030277819, 303027781X
Language
english
Format
PDF
Filesize
28 MB (28898199 bytes)
Edition
2
Pages
\239
Time added
2021-08-08 17:36:45

Description

Preface Contents 1: 18F-FDG 1.1 Synthesis 1.2 Pharmacokinetics 1.3 Physiological Distribution 1.4 Clinical Indications 1.4.1 Differentiation Between Benign and Malignant Lesions 1.4.2 Unknown Primary Tumor 1.4.3 Staging 1.4.4 Restaging 1.4.5 Assessment of Response to Therapy 1.4.6 Detection of Tumor Recurrence 1.4.7 Radiation Therapy Planning 1.4.8 Inflammation and Infection 1.4.9 Neuroimaging 1.4.10 Myocardial Viability 1.5 PET/CT Acquisition Protocols 1.6 PET/MRI 1.7 Variants and Pitfalls References 2: 18F-DOPA 2.1 Synthesis 2.2 Pharmacokinetics 2.3 Physiological Distribution 2.4 Clinical Indications 2.4.1 Neuroendocrine Tumors 2.4.2 Neuro-oncological Imaging 2.4.3 Functional Neuroimaging 2.5 Clinical Cases 2.6 PET/CT Acquisition Protocols 2.7 Variants and Pitfalls References 3: Lipogenesis Pathway: Radiolabeled Choline 3.1 Synthesis 3.2 Pharmacokinetics 3.3 Physiological Distribution 3.4 Clinical Indications 3.4.1 Prostate Cancer 3.4.2 Malignancies with High Lipogenesis Rate 3.4.3 Neuro-oncological Imaging 3.4.4 Functional Imaging 3.4.5 PET/MRI 3.5 Clinical Cases 3.6 PET/CT Acquisition Protocols 3.7 Variants and Pitfalls References 4: 18F-FET 4.1 Synthesis, Pharmacokinetics and Biodistribution of 18F-FET 4.2 18F-FET PET Acquisition Protocols 4.3 Indications of 18F-FET PET 4.3.1 Evaluation of Brain Tumours by 18F-FET PET 4.3.2 Comparison of 18F-FET with Other PET Radiopharmaceuticals for Brain Tumour Imaging References 5: 18F-NaF 5.1 Synthesis 5.2 Pharmacokinetics 5.3 Physiological Distribution 5.4 Clinical Indications 5.4.1 Bone Metastases 5.4.2 Benign Bone Disease 5.4.3 Forensic Use 5.5 Clinical Cases 5.6 PET/CT Acquisition Protocols 5.7 Variants and Pitfalls References 6: Somatostatin Receptor Analogs (68Ga-DOTATOC, 68Ga-DOTANOC, 68Ga-DOTATATE) 6.1 Synthesis 6.2 Pharmacokinetics 6.3 Physiological Distribution 6.4 Indications 6.4.1 Diagnosis, Staging, and Restaging of NET 6.4.2 Selection for Therapy 6.4.3 Assessment of the Response After Treatment 6.4.4 Tumors Other than Pulmonary and Gastrointestinal NETs 6.4.5 Combined Use of 18F-FDG and 68GA-DOTA-Peptides 6.5 Clinical Cases 6.6 PET/CT Acquisition Protocols 6.7 Variants and Pitfalls References 7: 64Cu-Radiopharmaceuticals 7.1 Copper: Physical and Biological Properties 7.2 Copper Chemistry 7.2.1 64Cu Coordination Numbers and Chelators 7.2.2 Criticisms for Copper Labeling 7.2.3 Copper Chelators 7.3 Copper-Labeled Radiopharmaceuticals 7.3.1 64Cu-PSMA 7.3.2 64Cu-ATSM 7.3.3 64Cu-DOTANOC and 64Cu-DOTATATE References 8: Amyloid Imaging 8.1 Synthesis 8.2 Pharmacokinetics 8.3 Physiological Distribution 8.4 Clinical Indications 8.4.1 Mild Cognitive Impairment 8.4.2 Alzheimer Disease and Other Kinds of Dementia 8.5 Clinical Cases 8.6 PET/CT Acquisition Protocols 8.7 Variants and Pitfalls References 9: PET Myocardial Perfusion Imaging: 82Rb 9.1 PET Myocardial Perfusion Tracers: Introduction 9.1.1 Labeled Water (15O-H2O) 9.1.2 13N Ammonia (13N-NH3) 9.2 Rubidium-82 9.2.1 Production and Kinetic 9.2.2 CardioGen-82® Quality Control Procedures 9.3 82Rb-PET/CT: Protocols 9.4 82Rb-PET/CT MBF—MFR 9.5 82Rb PET MPI Versus SPECT MPI 9.6 Clinical Applications 9.6.1 Multimodality Technique PET/CT 9.6.2 82Rb PET/CT in Obstructive and Nonobstructive CAD 9.6.3 82Rb PET/CT: Acute Coronary Syndrome 9.6.4 82Rb PET/CT: Heart Transplant 9.6.5 Myocardial Viability: A Look to the Past and Directions for the Future with 82Rb PET/CT 9.7 Costs 9.8 Dosimetry 9.9 Future Directions in Oncology Clinical Case N. 1: Follow-Up of Revascularized MVD: Capability of 82Rb PET/CT in Evaluating Transient ISCHEMIA Target for Vessel Clinical Case N. 2: Match Normoperfusion, No Significant Calcific Atheromasia Clinical Case N. 3: Transient Ischemia and Coronary Artery Calcific Atheromasia Clinical Case N. 4: Obstructive CAD Clinical Case N. 5: LV Pseudoaneurysm Clinical Case N. 6: 82Rb PET/CT in the Monitoring the Efficacy of Medical Therapy versus Progression Disease Clinical Case N. 7: Ischemic, Dysfunctional CMD Associated with Balanced Ischemia Clinical Case N. 8: 82Rb PET/CT MPI—Impaired Regional LV MBF Clinical Case N. 9: 82Rb PET/CT in the Emergency of Cath-lab References 10: The Bone Pathway: 223Ra-Dichloride 10.1 Background 10.2 223Ra and Pharmacokinetic 10.2.1 Isotope 10.2.2 Advantages of Alpha Particles 10.2.3 Xofigo 10.2.4 Radiation Protection Aspects 10.2.5 Pharmacokinetic 10.3 Dosimetric Distribution 10.3.1 Adverse Reaction 10.4 Clinical Indications 10.4.1 Phase II and III Trial 10.4.2 Clinical Issues 10.5 Planar Acquisition Protocols 10.6 Last Evidences 10.7 Future Trends References 11: 11C-Methionine 11.1 Synthesis 11.2 Pharmacokinetics 11.3 Physiological Distribution 11.4 Exam technique 11.5 Indications 11.5.1 Primary Brain Tumors 11.5.2 Metastases 11.5.3 Radiation Treatment Planning 11.5.4 Response to Therapy 11.5.5 Brain Tumor Recurrence versus Post-radiotherapy Necrosis 11.6 Variants and Pitfalls 11.7 New Trend 11.7.1 Myocardial Infarction 11.7.2 Hyperparathyroidism 11.7.3 Squamous Cell Head and Neck Cancer 11.7.4 Multiple Myeloma and Lymphoma References 12: 68Ga-PSMA 12.1 Synthesis 12.2 Pharmacokinetics 12.3 Physiological Distribution 12.4 Clinical Indications 12.5 PET Radioligands for Prostate Cancer Imaging 12.6 Clinical Cases 12.7 PET/CT Acquisition Protocols 12.8 Variants and Pitfalls References 13: PET Biomarkers for Tau Pathology 13.1 Tau PET Tracers 13.1.1 Synthesis 13.1.2 Pharmacokinetics 13.1.3 Physiological Distribution 13.1.4 Indications 13.1.5 Clinical Cases 13.1.6 Acquisition Protocols 13.1.7 Variants and Pitfalls References

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