Detection Methods in Precision Medicine

Description

Precision medicine is a topical subject that attracts tremendous attention from scientific and medical communities, being set to transform health care in the future. This book will be among the first to cover the detection methods for precision medicine. The first section provides an overview of the biomarkers used for precision medicine, such as proteins, nucleic acids, and metabolites. The coverage then turns to sequencing techniques and their applications, and other bioanalytical techniques, including mass spectrometry for proteome and phosphoproteome analysis, immunological methods and droplet technologies. The final sections include biosensors applied to precision medicine and clinical applications. This book provides a reference for researchers and students interested and working in the development of bioanalytical techniques for clinical applications. It provides a useful introduction for physicians and medical laboratory technologists to the recent advances in detection methods for precision medicine. Cover Copyright Detection Methods in Precision Medicine Preface Contents Part 1Biomarkers for Precision Medicine Chapter 1Genome-wideDiscovery ofMicroRNA Biomarkers forCancer Precision Medicine Chapter 2 Extracellular Vesicles in Precision Medicine O. Ruhena and K. Meehan* Chapter 3 Proteomics in Precision Medicine Jiangnan Zhenga, An Hea, Yiheng Maoa, Lijun Yanga, Chris SOON Heng Tan* Chapter 4 Computational Prediction of Tumor Neoantigen for Precision Oncology Shaojun Tang* Chapter 5 Big Data and Its Emerging Role in Precision Medicine and Therapeutic Response Nusrat J. Epsi† Chapter 6 Detection of Disease-associated Mutations and Biomarkers Using Next-generation Sequencing Jian Yan* Chapter 7 Nanopore Sequencing and Detection of Tumor Mutations Yu Chena, Xiaoy u Zhoua and Mengsu Yang* Chapter 8 Analytical Challenges of Next-generation Sequencing in Precision Medicine A. Matthew R Liebers* Chapter 9 Single-cell Sequencing of Circulating Tumor Cells: Recent Technical Advances, Challenges and Applications Ying Nia, Yu Chapter 10 Applications for Mass Spectrometry-based Proteomics and Phosphoproteomics in Precision Medicine Sara L. Banerjeea, Chapter 11 Immunological Detection Methods for Biomarkers King Hoo Lim† Chapter 12 Droplet Microfluidics for Precision Medicine Sze Nga Laia, Xiaofei Ouyanga and Bo Zheng* Chapter 13 POCT for Nucleic Acids by Using Colorimetric Nanoprobes Shiyao Wanga and Thomas M. H. Lee* Chapter 14 Cell and Immune Therapy Kevin Wijanarko† Chapter 15 Precision Oncology A. Matthew R. Liebers* Subject Index