Ultrasound of Mouse Fetal Development and Human Correlates

Description

Fetal development in the mouse is routinely and increasingly utilized for advancing translational research and medical innovation for human obstetrical care. This is the first and only manual to provide necessary content on how this should be handled for accurate and effective data collection. Detailed descriptions and examples demonstrate how researchers and clinicians can use murine fetal and obstetrical data to improve future human applications in diseases such as infertility, recurrent pregnancy loss, intrauterine fetal growth restriction, placental insufficiency, and intrauterine fetal demise, as well as organ-specific developmental disease. Cover Half Title Title Page Copyright Page Contents Acknowledgements Foreword Preface 1. Implantation and Embryonic Imaging: Mouse until D4.5-9.5; Human 5-9 Weeks Dating Imaging Preimplantation Development Decidualization and Early Implantation Human Mouse Development of Gestational Sac Human Mouse Detection of a Fetal Pole Human Mouse Fetal Polarity and Development of Basic Structures Human Mouse Establishment, Detection and Quantification of Cardiac Activity Human Mouse Fetal Heart Rate First Trimester Complications Early Pregnancy Loss Anembryonic Pregnancy (Blighted Ovum) First Trimester Spontaneous Abortion Development of Early Murine Fetal Growth Curve Summary References 2. Early Organogenesis and First Trimester: Mouse D10.5-12.5; Human 9-12 Weeks Imaging Organogenesis Cardiac Human Mouse Cardiac Anomalies Limb Buds Human Mouse Limb Anomalies Fetal Demise, Normal and Abnormal Fetal Growth Human Mouse First Trimester Fetal Growth Anomalies Head and Face Human Mouse Craniofacial Anomalies Characterization of Multifetal Gestation and Pregnancy Spacing Human Mouse References 3. Mid-Gestation and Second Trimester: Mouse D13.5-15.5; Human 13-27 Weeks Imaging Organogenesis Cardiac Human Mouse Cardiac Anomalies Diaphragm Overview Human Mouse Diaphragm Anomalies Extremities Human Mouse Paw and Hand Anomalies Long Bone and Limb Anomalies References 4. Central Nervous System and Facial Development: Mouse D13.5-15.5; Human 13-27 Weeks Imaging of Central Nervous System and Facial Development Central Nervous System and Facial Development Nasal Structures and Palate Human Mouse Anomalies Eye Human Mouse Anomalies Spine Human Mouse Anomalies Brain Human Mouse Anomalies References 5. Late-Gestation and Third Trimester: Mouse D16.5-18.5; Human 28-40 Weeks Kidneys Human Mouse Anomalies Heart Human Mouse Anomalies Eye and Orbit Human Mouse Anomalies Limbs, Hands, Feet and Paws Human Mouse Anomalies Face and Snout Human Mouse Anomalies Spine and Tail Human Mouse Anomalies Brain/CNS Human Mouse Anomalies References 6. Placenta Throughout Gestation Placenta Human Mouse Placental Anomalies Placenta Accreta/Percreta/Increta Placental Calcifications Cord Insertion References Index