Microdomains in the cardiovascular system

Description

The book comprehensively presents new findings in cardiovascular research related to signaling microdomains in health and disease. Important second messengers such as cAMP, cGMP, calcium and their role in microdomain signaling are discussed. The book offers and explains methodical approaches and technical ways how to successfully analyze microdomain signaling, also in the context of disease. It further provides scientific perspectives and strategies that are based on the concept of signaling within microdomains and that can revolutionize pharmacology and eventually lead to the effective treatment of cardiovascular diseases in future.This book is written for scientists in cardiovascular research, pharmacology, molecular and cellular biology as well as medical doctors in cardiology, angiology and nephrology. Front Matter ....Pages i-viii Front Matter ....Pages 1-1 Receptor-Cyclic Nucleotide Microdomains in the Heart (Nadja I. Bork, Viacheslav O. Nikolaev)....Pages 3-15 Membrane Microdomains and cAMP Compartmentation in Cardiac Myocytes (Shailesh R. Agarwal, Rennolds S. Ostrom, Robert D. Harvey)....Pages 17-35 Function to Failure: Compartmentalization of Cardiomyocyte Signaling by A-Kinase-Anchoring Proteins (John M. Redden, Kimberly L. Dodge-Kafka, Michael S. Kapiloff)....Pages 37-57 Pharmacological Approaches for Delineating Functions of AKAP-Based Signalling Complexes and Finding Therapeutic Targets (Katharina Schrade, Enno Klussmann)....Pages 59-83 Chatting Second Messengers: PIP3 and cAMP (Alessandra Ghigo, Flora Pirozzi, Mingchuan Li, Emilio Hirsch)....Pages 85-95 Cyclic Nucleotide Phosphodiesterases and Compartmentation in Normal and Diseased Heart (Ibrahim Bedioune, Pierre Bobin, Jérôme Leroy, Rodolphe Fischmeister, Grégoire Vandecasteele)....Pages 97-116 cAMP Compartmentalisation and Hypertrophy of the Heart: ‘Good’ Pools of cAMP and ‘Bad’ Pools of cAMP Coexist in the Same Cardiac Myocyte (Anna Zoccarato, Manuela Zaccolo)....Pages 117-141 Subcellular Targeting of PDE4 in Cardiac Myocytes and Generation of Signaling Compartments (Marco Conti)....Pages 143-160 Cardiac cAMP Microdomains and Their Modulation Using Disruptor Peptides (Lauren Wills, Bracy A. Fertig, George S. Baillie)....Pages 161-173 Computational Modeling of Cyclic Nucleotide Signaling Mechanisms in Cardiac Myocytes (Claire Y. Zhao)....Pages 175-213 Signalling Microdomains: The Beta-3 Adrenergic Receptor/NOS Signalosome (J. Hammond, J.-L. Balligand)....Pages 215-244 Compartmentation of Natriuretic Peptide Signalling in Cardiac Myocytes: Effects on Cardiac Contractility and Hypertrophy (Lise Román Moltzau, Silja Meier, Kjetil Wessel Andressen, Finn Olav Levy)....Pages 245-271 Cyclic GMP/Protein Kinase Localized Signaling and Disease Implications (Brian Leei Lin, David A. Kass, Dong I. Lee)....Pages 273-290 Front Matter ....Pages 291-291 Distribution and Regulation of L-Type Ca2+ Channels in Cardiomyocyte Microdomains (Alexey V. Glukhov, Anamika Bhargava, Julia Gorelik)....Pages 293-319 The Role of Local Ca2+ Release for Ca2+ Alternans and SR-Ca2+ Leak (Karin P. Hammer, Lars S. Maier)....Pages 321-340 The Control of Sub-plasma Membrane Calcium Signalling by the Plasma Membrane Calcium ATPase Pump PMCA4 (Nicholas Stafford, Ludwig Neyses, Delvac Oceandy)....Pages 341-359 Calcium Microdomains in Cardiac Cells (A. M. Gómez, T. R. R. Mesquita, J. J. Mercadier, J. L. Álvarez, J. P. Benitah)....Pages 361-386