ENGLISH

Chagas Disease: A Clinical Approach

By Jaime Marcelo Altcheh , Hector Freilij

Book information

Publisher
Springer International Publishing
Year
2019
ISBN
978-3-030-00053-0, 978-3-030-00054-7
Language
english
Format
PDF
Filesize
7 MB (7653308 bytes)
Series
Birkhäuser Advances in Infectious Diseases
Edition
1st ed. 2019
Pages
XII, 356\356
Time added
2020-02-08 04:40:59
Biomedicine; Molecular Medicine; Parasitology; Inf

Description

Chagas disease is a potentially life threatening condition that was historically mainly endemic to Latin America. Over the last decade, however, the disease has spread to and is increasingly prevalent in other continents such as North America and Europe, with an estimated 7 million people infected worldwide. It is primarily transmitted by insect vectors that carry the parasite Trypanosoma cruzi, the disease agent. In areas where there is vector control and in non-endemic countries, it is mainly transmitted via congenital infection. Cardiac and gastrointestinal complications are common in untreated individuals. This book offers a comprehensive overview of Chagas disease, including its vectorial and congenital transmission, and molecular diagnosis, which is essential for screening, and developing and providing timely, effective anti-trypanosomal treatment. Written by experts working with infected patients on a daily basis, it discusses the pathogenesis of congenital, cardiac, gastrointestinal and oral Chagas disease, as well as its treatment and the pharmacological aspects of drug development in this area. Chapter "Chagas Disease Treatment Efficacy Biomarkers: Myths and Realities" is available open access under a via link.springer.com. Front Matter ....Pages i-xii Front Matter ....Pages 1-1 Chagas Disease: Past, Present, and Future (Héctor Freilij)....Pages 3-22 Front Matter ....Pages 23-23 Trypanosoma cruzi Journey from the Insect Vector to the Host Cell (Catalina D. Alba Soto, Stella Maris González Cappa)....Pages 25-59 A Panoramic View of the Immune Response to Trypanosoma cruzi Infection (Gonzalo R. Acevedo, Magali C. Girard, Karina A. Gómez)....Pages 61-88 Front Matter ....Pages 89-89 Epidemiology of Chagas Disease (Roberto Chuit, Roberto Meiss, Roberto Salvatella)....Pages 91-109 Chagas Disease in Europe (Julio Alonso-Padilla, María Jesús Pinazo, Joaquim Gascón)....Pages 111-123 Chagas Disease in the United States (USA) (Melissa S. Nolan, Kyndall Dye-Braumuller, Eva Clark)....Pages 125-138 Front Matter ....Pages 139-139 Diagnosis of Chagas Disease (Alejandro O. Luquetti, Alejandro G. Schijman)....Pages 141-158 Front Matter ....Pages 159-159 Acute Vector-Borne Chagas Disease (Guillermo Moscatelli, Samanta Moroni)....Pages 161-178 Congenital Chagas Disease (Jaime Marcelo Altcheh)....Pages 179-198 Clinical Care for Individuals with Chronic Trypanosoma cruzi Infection: Decision-Making in the Midst of Uncertainty (Juan Carlos Villar, Pablo Andrés Bermudez)....Pages 199-224 Orally Transmitted Chagas Disease: Biology, Epidemiology, and Clinical Aspects of a Foodborne Infection (Belkisyolé Alarcón de Noya, Oscar Noya González)....Pages 225-241 Gastrointestinal Chagas Disease (Ênio Chaves de Oliveira, Alexandre Barcelos Morais da Silveira, Alejandro O. Luquetti)....Pages 243-264 Chagas Disease in Immunosuppressed Patients (Adelina R. Riarte, Marisa L. Fernandez, Claudia Salgueira, Javier Altclas)....Pages 265-296 Front Matter ....Pages 297-297 Clinical Pharmacology of Drugs for the Treatment of Chagas Disease (Facundo Garcia-Bournissen)....Pages 299-312 In Vivo Drug Testing for Experimental Trypanosoma cruzi Infection (Julián Ernesto Nicolás Gulin)....Pages 313-321 Chagas Disease Treatment Efficacy Biomarkers: Myths and Realities (Elizabeth Ruiz-Lancheros, Eric Chatelain, Momar Ndao)....Pages 323-349 Back Matter ....Pages 351-356

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