Silk-based Drug Delivery Systems
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Covering spider silk and silk worm cocoons, the editors elucidate the extraction, structure and properties of silk sericin and silk fibroin. Showing how these proteins are employed in micro and nano drug delivery systems, their use in pre-clinical and clinical trials, and closing with chapter on sustainability- driven innovation in the pharma industry, this book is ideal for graduates and researchers in biomaterials science and pharmaceutical science. Cover Silk-based Drug Delivery Systems Preface Acknowledgements Contents Chapter 1 - Micro and Nano-drug Delivery Systems 1.1 Introduction 1.2 Materials Used for Micro or Nano-drug Delivery Systems Preparation 1.2.1 Inorganic Materials 1.2.2 Organic Materials 1.3 Methods for Micro and Nano-drug Delivery Systems' Preparation and Drug Loading 1.3.1 Physical and Chemical Methods for the Production of Micro/Nanoparticles 1.3.2 Factors that Influence the Drug Loading into Micro/Nanoparticles 1.4 Therapeutic Applications of Micro and Nano-drug Delivery Systems 1.4.1 The Importance of Drug Targeting 1.4.2 Delivery and Targeting of RNA 1.4.3 Micro/Nano-drug Delivery Systems and Vaccination 1.4.4 Micro/Nanosystems for Skin Drug Delivery 1.4.5 Intraocular Drug Delivery by Micro/Nano-drug Delivery Systems References Chapter 2 - Silk 2.1 Introduction 2.2 Silk 2.2.1 Silkworm Silk: Mulberry and Non-mulberry 2.2.2 Spider Silk 2.2.3 Other Silk 2.3 Silk Proteins 2.3.1 Silk Fibroin and Spidroin 2.3.2 Silk Sericin 2.4 From Raw Silk to Fibroin or Sericin: the Degumming Process 2.5 Application of Silk Proteins as Biomaterials 2.5.1 Silk Fibroin and Spidroin as a Biomaterial 2.5.2 Silk Sericin as a Biomaterial References Chapter 3 - Silk-fibroin Micro-drug Delivery Systems 3.1 Introduction 3.2 Silk Fibroin Microparticles and Microspheres 3.3 Silk Fibroin Microcapsules 3.4 Silk Fibroin Microneedles 3.5 Silk Fibroin Microfibers References Chapter 4 - Silk-fibroin Nano-drug Delivery Systems 4.1 Introduction 4.2 Silk Fibroin Nanoparticles 4.2.1 Functionalised Silk Fibroin Nanoparticles 4.3 Silk Fibroin Nanocapsules 4.4 Silk Fibroin Nanofibers References Chapter 5 - Silk-sericin Micro-drug Delivery Systems 5.1 Introduction 5.2 Silk Sericin Microparticles and Microspheres 5.3 Silk Sericin Microcapsules References Chapter 6 - Silk-sericin Nano-drug Delivery Systems 6.1 Introduction 6.2 Silk Sericin Nanoparticles 6.3 Silk Sericin Nanofibers References Chapter 7 - Physico-chemical Characterisation of Silk-based Materials 7.1 Introduction 7.2 Thermal Analysis 7.3 Infrared Spectroscopy 7.4 Nuclear Magnetic Resonance Spectroscopy 7.5 X-ray Diffraction 7.6 Scanning Electron Microscopy References Chapter 8 - From Bench to Bedside: The Long Way Towards GMP Scale-up, Preclinical and Clinical Trials for Silk-based Drug Delivery Systems 8.1 Introduction 8.2 Silk-based Drug Delivery Systems in Preclinical Animal Models 8.3 Clinical Translation of Micro and Nano-drug Delivery Systems: The Specificity of Silk-based Ones 8.3.1 Technological Challenges: Scalable and GMP Preparation Procedures 8.3.2 Biological Challenges References Chapter 9 - From Textile to Pharmaceutical and Cosmetic Industry: Circular Economy Applied to Silk Manufacturing Wastes 9.1 Sustainability Matters 9.2 Pollution in Textiles 9.3 Circular Economy Is One Answer 9.4 The Silk Production Processes 9.4.1 Twisting 9.4.2 Yarn Dyeing 9.4.3 Fabric Weaving 9.4.4 Fabric Dyeing or Printing 9.4.5 Finishing 9.5 From Waste to Value 9.5.1 Upgrading Fibroin Waste 9.5.2 Sericin Recovery 9.6 Sustainability- and Circularity-related Benefits 9.7 Conclusions References Subject Index
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