Neurobiology of Personality Disorders
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Personality disorders are highly prevalent and cause a substantial amount of human suffering and harm-not only to the individuals and families directly affected, but also to the population at large. These disorders generally have a heritability rate that is in excess of fifty percent, strongly suggesting that the behavioral disturbance they cause have a significant biomedical etiology. However, knowledge about the biological nature of personality disorders-and effective treatment of the latter-is significantly lacking. Although basic biological principles have overall served well in the foundation of psychiatry, they have received relatively little attention with regard to the areas of personality, temperament, and personality disorders. Neurobiology of Personality Disorders is the first book to focus specifically on the neurobiology of disturbed personality. It provides a thorough outline of the principles of neural science that mediate personality and describe what is currently known about how these biological processes are impaired in individuals with personality disorders. Its team of editors and authors are among the most frequently published and highly renowned international neuroscientists in the field of personality disorders, and its coverage of topics is comprehensive, authoritative, and heuristic. Cover Neurobiology of Personality Disorders Copyright Contents Preface Contributors Section I Foundations of Neurobiology of Personality 1 Neurocircuitry of Affective, Cognitive, and Regulatory Systems 2 The Fundamentals of Brain Neurotransmission 3 Genetics of Personality Disorders 4 Cognitive Neuroscience Approaches to Personality Disorders 5 Minding the Emotional Thermostat: Integrating Social Cognitive and Affective Neuroscience Evidence to Form a Model of the Cognitive Control of Emotion 6 The Neurobiology of Attachment and Mentalizing: A Neurodevelopmental Perspective Section II Critical Domains/Dimensions of Brain Function/Circuits for Personality and Its Disorders 7 Emotion Regulation 8 The Clinical Neuroscience of Impulsive Aggression 9 Social Cognition in Personality Disorders 10 Attachment in Personality Disorders 11 Suicide and Nonsuicidal Self-Injury: Prevalence in Patients with Personality Disorders Section III Neurobiology of Categorical Diagnoses of Personality Disorder 12 The Neurobiology and Genetics of Schizotypal Personality Disorder 13 The Neurobiological Basis of Borderline Personality Disorder 14 The Neurobiology of Antisocial Personality Disorders Focusing on Psychopathy 15 The Neurobiological Basis of Avoidant Personality Disorder Section IV Implications for Diagnostic Systems and Treatment 16 Established and Novel Pharmacological Approaches to the Treatment of Personality Disorders 17 Neurobiological Underpinnings of Psychosocial Treatment in Personality Disorders 18 Conclusions and Future Directions Index
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