Frontiers of Cord Blood Science
Book information
Description
Since the first successful transplantation of umbilical cord blood in 1988, cord blood has become an important source of hematopoietic stem and progenitor cells for the treatment of blood and genetic disorders. Significant progress has been accompanied by challenges for scientists, ethicists, and health policy makers. With the recognition of the need for a national system for the collection, banking, distribution, and use of cord blood and the increasing focus on cord blood as an alternative to embryos as a source of tissue for regenerative medicine, it has garnered significant attention recently. Frontiers in Cord Blood Science contains chapters from distinguished investigators currently engaged in researching cord blood in the treatment of various diseases of the brain, heart, liver, pancreas, bone and cartilage. The current state of research in the field is presented and the potential future applications of cord blood both for research and for the treatment of different diseases and conditions is discussed. In addition, the book reviews the possibility for novel uses in surgical wound healing and in synthetic grafts for reconstructive surgery, allowing their better adhesion. Investigating the ethical issues, this book will be of interest to all scientists and researchers within the field of regenerative medicine and also clinicians in dermatology, neurology, cardiology and orthopedics wishing to discover more about the potential for the revolutionary medical approach of human umbilical cord blood. Front Matter....Pages i-xxix Front Matter....Pages 1-1 Placental and Pregnancy Stem Cells....Pages 1-18 Cord Blood Stem Cells – The Basic Science....Pages 19-25 Stem Cells from Umbilical Cord Blood....Pages 27-90 Ex Vivo Expansion of Cord Blood....Pages 91-96 Mesenchymal Stem Cells: Applications in Cell and Gene Therapy....Pages 97-122 Non-hematopoietic Stem and Progenitor Cells Derived From Human Umbilical Cord Blood....Pages 123-157 Front Matter....Pages 1-1 Cord Blood Transplantation for Pediatric Non-Malignant Conditions....Pages 161-194 Cord Blood Transplantation for Hematologic Malignancies....Pages 195-208 Double Umbilical Cord Blood Transplantation in Adults....Pages 209-223 Front Matter....Pages 1-1 Placental Umbilical Cord Whole Blood Transfusion: A True Blood Substitute to Combat Anemia in the Background of Chronic Disease – A Study Report (1999–2006)....Pages 227-263 Umbilical Cord Blood Therapy in Neurology....Pages 265-272 Cord Blood: Opportunities and Challenges for the Reconstructive Surgeon....Pages 273-287 Umbilical Cord Blood Transfusion – A Clinical Overview....Pages 289-295 Front Matter....Pages 1-1 Establishment of the UK Stem Cell Bank and Its Role in Stem Cell Science....Pages 299-306 Cord Blood Allogeneic and Autologous Banking....Pages 307-315 Front Matter....Pages 1-1 Possibilities of Using Cord Blood for Improving the Biocompatibility of Implants....Pages 319-330 Potential of Stem Cell to Tailor the Bone-Ceramic Interface for Better Fixation of Orthopedic Implants....Pages 331-357 Front Matter....Pages 1-1 Some Aspects of the Ethics of Stem Cell Research....Pages 361-367 Back Matter....Pages 369-374
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