Introduction to Basics of Pharmacology and Toxicology: Volume 1: General and Molecular Pharmacology: Principles of Drug Action

Description

This book illustrates, in a comprehensive manner, the most crucial principles involved in pharmacology and allied sciences. The title begins by discussing the historical aspects of drug discovery, with up to date knowledge on Nobel Laureates in pharmacology and their significant discoveries. It then examines the general pharmacological principles - pharmacokinetics and pharmacodynamics, with in-depth information on drug transporters and interactions. In the remaining chapters, the book covers a definitive collection of topics containing essential information on the basic principles of pharmacology and how they are employed for the treatment of diseases. Readers will learn about special topics in pharmacology that are hard to find elsewhere, including issues related to environmental toxicology and the latest information on drug poisoning and treatment, analytical toxicology, toxicovigilance, and the use of molecular biology techniques in pharmacology. The book offers a valuable resource for researchers in the fields of pharmacology and toxicology, as well as students pursuing a degree in or with an interest in pharmacology. Front Matter ....Pages i-xviii Front Matter ....Pages 1-1 The Great Pharmacologists and Their Revolutionary Discoveries (Gerard Marshall Raj)....Pages 3-39 Indian Contributions to Pharmacology (Sakthibalan Murugesan, Mangaiarkkarasi Adhimoolam)....Pages 41-57 Front Matter ....Pages 59-59 Sources and Nature of Drugs (Avinash Arivazhahan)....Pages 61-68 Principles and Modes of Drug Administration (Avinash Arivazhahan)....Pages 69-79 Drug Absorption and Bioavailability (Abialbon Paul)....Pages 81-88 Drug Distribution (Abialbon Paul)....Pages 89-98 Drug Metabolism (Mageshwaran Lakshmanan)....Pages 99-116 Drug Elimination (Elavarasi Pichai, Mageshwaran Lakshmanan)....Pages 117-129 Mechanisms of Drug Action (Abialbon Paul)....Pages 131-153 Drug Transporters (Rekha Priyadarshini)....Pages 155-176 Adverse Effects and Pharmacovigilance (Avinash Arivazhahan, Sushil Kiran Kunder)....Pages 177-196 Drug Interactions (Heta Shah, Neel Jayesh Shah)....Pages 197-204 Structure-Activity Relationships (Mageshwaran Lakshmanan)....Pages 205-219 Front Matter ....Pages 221-221 Drug Information (Nishanthi Anandabaskar)....Pages 223-234 Pharmacogenetics, Pharmacogenomics, and Personalized Medicine (Gerard Marshall Raj)....Pages 235-259 Chronopharmacology (Nishanthi Anandabaskar)....Pages 261-270 Pharmacoepidemiology (Nishanthi Anandabaskar)....Pages 271-280 Ethnopharmacology (Mageshwaran Lakshmanan)....Pages 281-296 Pharmacoeconomics (Nishanthi Anandabaskar)....Pages 297-301 Orphan Diseases and Drugs (Nishanthi Anandabaskar)....Pages 303-306 Fixed-Dose Combinations (Abialbon Paul)....Pages 307-312 Translational and Reverse Pharmacology (Abialbon Paul)....Pages 313-317 Gene Therapy (Arun Chander Yadav, Gopisankar MG)....Pages 319-328 Stem Cell Therapy (Panneer Devaraju, Damayandhi Kaliyaperumal, Thirumurthy Madhavan)....Pages 329-342 Principles of Prescription Writing (Heta Shah)....Pages 343-347 Front Matter ....Pages 349-349 Environmental Toxicology (Nishanthi Anandabaskar)....Pages 351-359 Basic Principles of Management of Drug Poisoning (Nishanthi Anandabaskar)....Pages 361-377 Front Matter ....Pages 379-379 Regulation of Gene Expression (Neel Jayesh Shah)....Pages 381-385 Proteomics (Neel Jayesh Shah)....Pages 387-389 Techniques Involved in Studying Receptor Dynamics (Neel Jayesh Shah)....Pages 391-394 Polymerase Chain Reaction (Neel Jayesh Shah)....Pages 395-397 Southern, Western and Northern Blotting (Neel Jayesh Shah)....Pages 399-406 Antisense Oligonucleotides (Neel Jayesh Shah)....Pages 407-411 Recombinant DNA Technology (Neel Jayesh Shah)....Pages 413-417