ENGLISH

TRAIL (TNF-Related Apoptosis-Inducing Ligand)

By Gerald Litwack (Eds.)

Book information

Publisher
Academic Press
Year
2004
ISBN
0127098674, 9780127098678
ISSN
0083-6729
Open Library ID
OL22114098M
Language
english
Format
PDF
Filesize
7 MB (6862839 bytes)
Series
Vitamins & Hormones 67
Edition
1
Pages
1-496\492
Time added
2011-06-04 13:46:07

Description

The discovery of TRAIL (TNF Related Apoptosis Inducing Ligand), also referred to as Apo-2, is in an era of intense research because TRAIL induces many cancer cells to undergo programmed cell death (apoptosis), while having no effect on normal cells. This important protein deserves extensive review at a formative time in the devlopement of our knowledge concerning its mechanism of action and the ways in which it can be used as a cancer chemotherapeutic agent. Consequently, this voume reviews the current status of research on TRAIL. Selected Contents:* Crystal Structure of RANK Ligand involved in bone metabolism* Promoter of TRAIL-R2 Gene* Monoclonal Antibodies against TRAIL* Modulation of TRAIL signaling complex* TRAIL in the airways* FLIP Protein and TRAIL-Induced Apoptosis* TRAIL and Ceramide* TRAIL and Viral Infection* TRAIL and Malignant Glioma

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