Handbook of Clinical Neurology. Multiple Sclerosis and Related Disorders

Description

Volume 122, Elsеviеr, 2014 - 703 pages, ISBN: 0444520015 044463309X 9780444633095 9780444520012 This collection of review chapters provides a comprehensive reference into the science and clinical applications of the latest Multiple Sclerosis research and will be a valuable resource for the neuroscience research community and the clinical neurology community of researchers and practitioners.Multiple Sclerosis (MS) is generally understood to be an inflammatory autoimmune disease of the central nervous system. While we still are not certain of the root cause of MS, research results suggest that unknown environmental factors and the presence of specific genes seem the most probable targets. MS causes an inflammatory response in the central nervous system leading to neurodegeneration, oligodendrocyte death, axonal damage, and gliosis. Over the past five years ongoing research has greatly expanded our understanding of the pathogenesis of MS, detailed insight into the epidemiology and genetic factors related to MS, the introduction of new technologies and tests to better diagnose and predict the future course of the disease and the introduction of new treatments targeting MS. A comprehensive tutorial reference detailing our current foundational understanding of Multiple Sclerosis Includes chapters on key topics including the genetics of MS, MRI imaging and MS, and the latest treatment options Each chapter is translational and focuses on current research and impact on diagnosis and treatment options.Contents Foreword Preface Contributors SECTION 1 Pathogenesis Immune regulation of multiple sclerosis Pathology of multiple sclerosis and related inflammatory demyelinating diseases The good and the bad of neuroinflammation in multiple sclerosis Demyclination in multiple sclerosis Axonal loss in multiple sclerosis: causes and mechanisms Insights from magnetic resonance imaging Infections and multiple sclerosis The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment SECTION 2 Epidemiology and genetics Multiple sclerosis genetics Genetics of primary progressive multiple sclerosis The epidemiology of multiple sclerosit: insights to disease pathogenesis SECTION 3 Diagnosis and disease course Multiple sclerosis: diagnosis, differential diagnosis, and clinical presentation MRI mimies of multiple sclerosis Diagnosis of multiple sclerosis The clinical course of multiple sclerosis Early prognosis of multiple sclerosis Clinical outcome measures in multiple sclerosis MKI outcomes in the diagnosis and disease course of multiple sclerosis Multiple sclerosis in children SECTION 4 Treatment Clinical trials in multiple sclerosis Glucocorticoid treatment of multiple sclerosis Disease-modifying agents in multiple sclerosis Immunosuppressive treatments in multiple sclerosis Symptomatic treatment and management of multiple sclerosis Future treatment approaches to multiple sclerosis SECTION 5 Other demyelinating diseases Neuromyelitis optica (Devic's syndrome) Acute disseminated encephalomyelitis and other inflammatory demyelinating variants Acute inflammatory myelopathies SECTION 6 Capita selecta Clinical neurophysiology of multiple sclerosis Cerebrospinal fluid analysis Index