ENGLISH

Drug Resistance in Leishmania Parasites: Consequences, Molecular Mechanisms and Possible Treatments

By Alicia Ponte-Sucre , Maritza Padrón-Nieves

Book information

Publisher
Springer International Publishing
Year
2018
ISBN
978-3-319-74185-7;978-3-319-74186-4
Language
english
Format
PDF
Filesize
6 MB (6164049 bytes)
Edition
2nd ed.
Pages
XVII, 376\380
Time added
2019-01-12 07:41:41
Biomedicine; Drug Resistance; Infectious Diseases;

Description

Drug resistance is a fundamental factor in treatment failure in diseases like leishmaniasis, although additional factors also play a role in this phenomenon. This volume is the second edition of a well-received book that provides a comprehensive update on the pathology of the disease, as well as on the concept of parasitic drug resistance, its molecular basis, consequences and possible treatments. A valuable resource for scientists both from academia and industry involved in biomedical research and drug design, the book provides the knowledge needed to understand leishmaniasis and to contibute to combatting this disease worldwide. Front Matter ....Pages i-xvii Leishmaniasis: The Biology of a Parasite (Emilia Díaz, Alicia Ponte-Sucre)....Pages 1-16 Front Matter ....Pages 17-17 Molecular Evolution and Phylogeny of Leishmania (Gabriele Schönian, Julius Lukeš, Olivia Stark, James A. Cotton)....Pages 19-57 The Role of Reservoirs: Canine Leishmaniasis (Lenea Campino, Carla Maia)....Pages 59-83 Epidemiology of Leishmaniasis in the Time of Drug Resistance (the Miltefosine Era) (Jean-Claude Dujardin)....Pages 85-107 The Role of the Immune System in Resistance to Infection (Lukasz Kedzierski, Krystal J. Evans)....Pages 109-142 Front Matter ....Pages 143-143 Co-infection with HIV (Margriet den Boer, Jorge Alvar)....Pages 145-158 Visceral Leishmaniasis (Shyam Sundar, Jaya Chakravarty)....Pages 159-176 American Tegumentary Leishmaniasis (Olga Zerpa, Maritza Padrón-Nieves, Alicia Ponte-Sucre)....Pages 177-191 The Challenges of Effective Leishmaniasis Treatment (Sarah Hendrickx, Louis Maes, Simon L. Croft, Guy Caljon)....Pages 193-206 Front Matter ....Pages 207-207 The Role of Proteomics in the Study of Drug Resistance (Leonardo Saboia-Vahia, Jose Batista de Jesus, Patricia Cuervo)....Pages 209-245 The Role of ABC Transporters in Drug-Resistant Leishmania (Adriano C. Coelho, Paulo C. Cotrim)....Pages 247-272 Functional Analysis of Leishmania Membrane (Non-ABC) Transporters Involved in Drug Resistance (Scott M. Landfear)....Pages 273-294 Front Matter ....Pages 295-295 Bioinformatics in Leishmania Drug Design (Shishir K. Gupta, Thomas Dandekar)....Pages 297-317 P-Glycoprotein-Like Transporters in Leishmania: A Search for Reversal Agents (Bruno Pradines)....Pages 319-340 The Concept of Fitness in Leishmania (Manu Vanaerschot, Franck Dumetz, Marlene Jara, Jean-Claude Dujardin, Alicia Ponte-Sucre)....Pages 341-366 Back Matter ....Pages 367-376

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