Oxygen Transport to Tissue XLII

Description

This book presents cutting-edge papers and perspectives on the transport of oxygen to tissues by scientists in a multitude of disciplines such as biochemistry, engineering, mathematics, medicine, physics, physiology, veterinary and complementary medicine. The book is composed of the following 6 parts: Brain Oxygenation and Function, Tumor Oxygenation and Metabolism, Muscle Oxygenation and Sports Medicine, Cell Metabolism and Tissue Oxygenation, Methodology of O2 Measurements, and Special Topics. The articles in this book have been presented at the 42nd annual meeting of the International Society on Oxygen Transport to Tissue (ISOTT 2019) held in Albuquerque, New Mexico, USA, from July 28 to July 31, 2019. Academics, clinical and industry researchers, engineers, as well as graduate students who are interested in oxygen transport to tissue will find this book a great reference and a useful learning resource. Preface Contents Part I: Oxygen Metabolism and Health Monitoring 1: Chronic Ketosis Modulates HIF1α-Mediated Inflammatory Response in Rat Brain 1.1 Introduction 1.2 Methods 1.3 Results 1.4 Discussion References 2: Event-Related NIRS and EEG Analysis for Mental Stress Monitoring 2.1 Introduction 2.2 Methods 2.3 Results 2.4 Discussion References 3: Simulation Study of Breast Cancer Lipid Changes Affecting Membrane Oxygen Permeability: Effects of Chain Length and Cholesterol 3.1 Introduction 3.2 Methods 3.3 Results and Discussion 3.4 Conclusions References 4: Updated Evaluation of Cholesterol’s Influence on Membrane Oxygen Permeability 4.1 Introduction 4.2 Methods 4.3 Results and Discussion 4.4 Conclusions References 5: Systems Biology Model of Cerebral Oxygen Delivery and Metabolism During Therapeutic Hypothermia: Application to the Piglet Model 5.1 Introduction 5.2 Methods 5.3 Result 5.4 Discussion References 6: Effect of Adrenaline on Cerebral Blood Oxygenation Measured by NIRS in a Rat Asphyxia Cardiac Arrest Model 6.1 Introduction 6.2 Methods 6.2.1 Animal Preparation 6.2.2 Statistical Analysis 6.3 Results 6.4 Discussion 6.5 Conclusion References 7: Two Consecutive Invasive Surgeries Utilizing Zymogen Protein C (ZPC) That Enhanced Patient Safety and Reduced Costs 7.1 Introduction 7.2 Case Presentation 7.3 Discussion References 8: Scanning Tissue Oxygen Needle Probe 8.1 Introduction 8.2 Sensor Design 8.2.1 Oxygen Sensing by Phosphorescence 8.2.2 Needle Probe Optical Scanner Design 8.3 Simulation Study 8.4 In Vivo Pilot Study 8.5 Conclusions References 9: Transcranial Photobiomodulation of Clearance of Beta-Amyloid from the Mouse Brain: Effects on the Meningeal Lymphatic Drainage and Blood Oxygen Saturation of the Brain 9.1 Introduction 9.2 Methods 9.3 Results 9.3.1 The Effects of tPBM on the Level of Aβ in the Mouse Brain with AD 9.3.2 Mechanisms of Therapeutic Effects of tPBM in Mice with AD 9.4 Conclusions References 10: Near-Infrared Spectroscopy Might Help Prevent Onset of Cerebral Hyperperfusion Syndrome 10.1 Introduction 10.2 Methods 10.2.1 Patient Preparation 10.2.2 Statistical Analysis 10.3 Results 10.4 Discussion 10.5 Conclusion References Part II: Oxygen Measurement and Modeling 11: Online Assessment of Hemodynamics in the Suctioned Volume of Biological Tissue by an Embedded Near-Infrared Spectroscopy Sensor 11.1 Introduction 11.2 Materials and Methods 11.3 Results 11.4 Discussion References 12: Skeletal Muscle Deoxygenation and Its Relationship to Aerobic Capacity During Early and Late Stages of Aging 12.1 Introduction 12.2 Methods 12.2.1 Subjects 12.2.2 Experimental Design 12.2.3 Statistical Analysis 12.3 Results 12.4 Discussion References 13: Near-Infrared Spectroscopy (NIRS) of Muscle HbO2 and MbO2 Desaturation During Exercise 13.1 Introduction 13.2 Material and Methods 13.3 Results (Figs. 13.1, 13.2, and 13.3) 13.4 Discussion and Conclusions References 14: Relationship Between Corticosteroid Dose and Muscle Oxygen Consumption in Recipients of Hematopoietic Stem-Cell Transplantation 14.1 Introduction 14.2 Methods 14.2.1 Participants 14.2.2 Experimental Procedure 14.2.3 NIRS Measurements 14.2.4 Statistical Analysis 14.3 Results 14.4 Discussion References 15: Relationship Between the Borg Scale Rating of Perceived Exertion and Leg-Muscle Deoxygenation During Incremental Exercise in Healthy Adults 15.1 Introduction 15.2 Methods 15.2.1 Participants 15.2.2 Experimental Procedure 15.2.3 NIRS Measurements 15.2.4 Statistical Analysis 15.3 Results 15.4 Discussion References 16: Effects of Exercise Training on Cardiac and Skeletal Muscle Functions in Patients with Chronic Heart Failure 16.1 Introduction 16.2 Methods 16.2.1 Subjects 16.2.2 Exercise Testing 16.2.3 CO Measurement 16.2.4 Skeletal Muscle Oxygenation Measurement 16.2.5 Statistical Analysis 16.3 Results 16.3.1 Comparison Between CHFpre and CON 16.3.2 Comparison Between CHFpre and CHFpost 16.4 Discussion 16.5 Conclusion References 17: Reduced Scattering Coefficient During Incremental Exercise Is Constant Without Being Affected by Changes in Muscle Oxygenation or Hemodynamics 17.1 Introduction 17.2 Methods 17.3 Results 17.4 Discussion and Conclusions References 18: Changes in the Laterality of Oxygenation in the Prefrontal Cortex and Premotor Area During a 20-Min Moderate-Intensity Cycling Exercise 18.1 Introduction 18.2 Methods 18.2.1 Participants 18.2.2 Experimental Procedure 18.2.3 NIRS Measurements 18.2.4 Blood Pressure and SBF Measurements 18.2.5 Statistical Analysis 18.3 Results 18.4 Discussion References 19: Relationship Between Decrease of Oxygenation During Incremental Exercise and Partial Pressure End-Tidal Carbon Dioxide: Near-Infrared Spectroscopy Vector Analysis 19.1 Introduction 19.2 Methods 19.2.1 Participants and Procedures 19.2.2 Cortical Oxygenation 19.2.3 PETCO2 and SBF 19.2.4 Statistical Analysis 19.3 Results 19.4 Discussion References 20: Cerebral Oxygenation Dynamics During Incremental Exercise: Comparison of Arm Cranking and Leg Cycling 20.1 Introduction 20.2 Methods 20.3 Results 20.4 Discussion References 21: Localization of Deep Ischemia and Hemorrhage in Preterm Infants’ Head with Near-Infrared Optical Tomography: A Numerical Case Study 21.1 Introduction 21.2 Methods 21.2.1 Forward Model 21.2.2 Image Reconstruction 21.2.3 Evaluation Parameters 21.3 Results and Discussion 21.4 Conclusion and Outlook References 22: Discerning Membrane Steady-State Oxygen Flux by Monte Carlo Markov Chain Modeling 22.1 Introduction 22.2 Methods 22.3 Results and Discussion 22.4 Conclusions and Expansion of the Model References Part III: Tumor Oxygenation and Modeling 23: The Role of MicroRNA Expression for Proliferation and Apoptosis of Tumor Cells: Impact of Hypoxia-Related Acidosis 23.1 Introduction 23.2 Methods 23.2.1 Cell Line 23.2.2 Experimental Settings 23.3 Results 23.4 Conclusion References 24: Functional Impact of Acidosis-Regulated MicroRNAs on the Migration and Adhesion of Tumor Cells 24.1 Introduction 24.2 Methods 24.2.1 Cell Line 24.2.2 Experimental Settings 24.3 Results 24.4 Conclusion References 25: Impact of Acidosis-Regulated MicroRNAs on the Expression of Their Target Genes in Experimental Tumors In Vivo 25.1 Introduction 25.2 Methods 25.2.1 Cell Culture and In Vivo Tumor Models 25.2.2 Experimental Settings 25.3 Results 25.4 Conclusion References 26: An Observation on Enhanced Extracellular Acidification and Lactate Production Induced by Inhibition of Lactate Dehydrogenase A 26.1 Introduction 26.2 Methods 26.3 Results 26.4 Discussion and Conclusion References 27: The Warburg Effect: Historical Dogma Versus Current Rationale 27.1 Introduction 27.2 The Warburg Effect: Essential Part of Metabolic Reprogramming and Favoring Biosynthesis Pathways 27.2.1 Major Biochemical Steps of Aerobic Glycolysis 27.2.2 The Warburg Effect and Energy Homeostasis 27.2.3 The Warburg Effect Ensures Redox Homeostasis and Reduces ROS Production 27.3 Regulatory Network of the Warburg Effect 27.4 Warburg Effect: The Role of Lactate Accumulation and Extracellular Acidosis 27.5 Conclusions References 28: The Acidic Tumor Microenvironment Affects Epithelial-Mesenchymal Transition Markers as Well as Adhesion of NCI-H358 Lung Cancer Cells 28.1 Introduction 28.2 Methods 28.2.1 Cell Line 28.2.2 Experimental Settings 28.3 Results 28.4 Conclusions References 29: Assessment of the Probability of Tumour Control for Prescribed Doses Based on Imaging of Oxygen Partial Pressure 29.1 Introduction 29.2 Methods 29.3 Results and Discussion 29.4 Conclusions References 30: On the Feasibility of Skin Water Content Imaging Adjuvant to Tissue Oximetry 30.1 Introduction 30.2 Methods 30.2.1 Imaging 30.2.2 Processing 30.3 Results 30.4 Conclusions References 31: Mechanisms of Sound-Induced Opening of the Blood-Brain Barrier 31.1 Introduction 31.2 Methods 31.3 Results 31.3.1 Blood-Brain Barrier Opening to High-Molecular-Weight Molecules 31.3.2 Systemic and Metabolic Responses Induced by Loud Sound 31.3.3 Sound-Induced Changes in TJ Machinery 31.3.4 Sound-Induced BBB Opening Is Associated with Activation of Lymphatic Clearance of Molecules Crossing the Opened BBB 31.4 Conclusions References 32: Multimodal Measurements of Brain Tissue Metabolism and Perfusion in a Neonatal Model of Hypoxic-Ischaemic Injury 32.1 Introduction 32.2 Methods 32.2.1 Animal Model of HI 32.2.2 Measurements of Cerebral Metabolism 32.2.3 Data Analysis 32.3 Results 32.4 Discussion References 33: Cerebral Spreading Depression Transient Disruption of Cross-Frequency Coupling in the Rat Brain: Preliminary Observations 33.1 Introduction 33.2 Material and Methods 33.2.1 Animal Model 33.2.2 Recording System and Electrodes 33.2.3 Data Analysis 33.3 Results 33.4 Discussion and Conclusions References 34: Long-Term Blue Light Exposure Changes Frontal and Occipital Cerebral Hemodynamics: Not All Subjects React the Same 34.1 Introduction 34.2 Material and Methods 34.3 Results 34.4 Discussion and Conclusions References 35: Changes in Prefrontal Cortex Asymmetry Due to Standing Load in Stroke Patients Measured by NIRS 35.1 Introduction 35.2 Methods 35.2.1 Subjects 35.2.2 NIRS Measurements 35.2.3 Data Analysis 35.3 Results 35.4 Discussion 35.5 Conclusions References 36: Parasympathetic Nervous Activity Associated with Discoordination Between Physical Acceleration and Heart Rate Variability in Patients with Sleep Apnea 36.1 Introduction 36.2 Methods 36.2.1 Subjects 36.2.2 Protocols 36.2.3 Oxygen Desaturation Index 36.2.4 Questionnaire 36.2.5 Physical Acceleration 36.2.6 Analysis 36.2.7 Statistics and Ethics 36.3 Results 36.4 Discussion References 37: The Changes in Brain Oxygenation During Transcranial Alternating Current Stimulation as Consequences of Traumatic Brain Injury: A Near-Infrared Spectroscopy Study 37.1 Introduction 37.2 Methods 37.2.1 tACS 37.2.2 Cerebral Oximetry 37.2.3 Statistical Analysis 37.3 Results 37.4 Discussion 37.5 Conclusion References 38: Error Evaluation for Automated Diameter Measurements of Cerebral Capillaries Captured with Two-Photon Laser Scanning Fluorescence Microscopy 38.1 Introduction 38.2 Methods 38.3 Results 38.4 Discussion References 39: Potential Biomarker for Triple-Negative Breast Cancer Invasiveness by Optical Redox Imaging 39.1 Introduction 39.2 Materials and Methods 39.3 Results 39.4 Discussion and Conclusions References 40: Optical Redox Imaging Differentiates Triple-Negative Breast Cancer Subtypes 40.1 Introduction 40.2 Methods 40.2.1 Cell Culture and Perturbation Drugs 40.2.2 Live Cell Optical Redox Imaging and Analysis 40.3 Results and Discussion 40.3.1 ORI Differentiates TNBC Cell Lines 40.3.2 ORI Detects Metabolic Changes in TNBC Cell Lines 40.3.3 TNBC Cell Lines Have Differential FAD and Redox Ratio Plasticity References 41: Oxygen-Sensing Paramagnetic Probes for Clinical Oximetry 41.1 Introduction 41.2 EPR Oxygen Sensors 41.2.1 SPOTChip for Topical Oximetry 41.2.2 MicroChip for Superficial (1–5-mm Depth) Tissue Oximetry 41.2.3 OxyChip for Shallow-Depth (10 mm) Oximetry 41.3 Oxygen Sensor Applications 41.4 Conclusion References 42: Evaluation of the Quality of Chest Compression with Oxyhemoglobin Level by Near-Infrared Spectroscopy in a Rat Asphyxia Cardiac Arrest Model 42.1 Introduction 42.2 Methods 42.2.1 Animal Preparation 42.2.2 Cardiopulmonary Resuscitation 42.2.3 Statistical Analysis 42.3 Results 42.4 Discussion 42.5 Conclusion References 43: Altered Behavioral Performance in the Neuron-Specific HIF-1- and HIF-2-Deficient Mice Following Chronic Hypoxic Exposure 43.1 Introduction 43.2 Methods 43.2.1 Animals and Hypoxic Exposure 43.2.2 Behavioral Performance 43.2.3 Statistical Analysis 43.3 Results 43.4 Discussion References 44: Effect of Adrenaline on Cerebral Blood Oxygenation Measured by NIRS in a Rat Asphyxia Cardiac Arrest Model 44.1 Introduction 44.2 Methods 44.2.1 Animal Preparation 44.2.2 Statistical Analysis 44.3 Results 44.4 Discussion 44.5 Conclusion References 45: Addition of Drag-Reducing Polymers to Colloid Resuscitation Fluid Enhances Cerebral Microcirculation and Tissue Oxygenation After Traumatic Brain Injury Complicated by Hemorrhagic Shock 45.1 Introduction 45.2 Methods 45.3 Results 45.4 Discussion 45.5 Conclusion References 46: Effects of 20-Minute Intensive Exercise on Subjects with Different Working Memory Bases 46.1 Introduction 46.2 Methods 46.3 Results 46.4 Discussion 46.5 Conclusions References 47: Supine Cycling Exercise Enhances Cerebral Oxygenation of Motor-Related Areas in Healthy Male Volunteers 47.1 Introduction 47.2 Methods 47.3 Results 47.4 Discussion References 48: What Is the Meaning of an Oxygen Measurement? 48.1 Introduction 48.2 Analysis of the Ability of Clinically Available Techniques to Measure Absolute Levels of O2 and/or Resolve Heterogeneity of O2 Distributions in Tissues 48.2.1 Direct Measures of O2 in Targeted Tissues 48.2.2 Direct Measures of O2 in the Vascular System 48.2.3 Indirect Measures of Tissue Oxygen 48.3 Discussion 48.4 Conclusions References Part IV: Brain Oxygenation and Function 49: Assessment of Cerebral Blood Oxygenation by Near-Infrared Spectroscopy before and after Resuscitation in a Rat Asphyxia Cardiac Arrest Model 49.1 Introduction 49.2 Methods 49.2.1 Animal Surgical Procedure 49.2.2 Statistical Analysis 49.3 Results 49.4 Discussion 49.5 Conclusions References 50: Effect of 3-Day and 21-Day Hypoxic Preconditioning on Recovery Following Cerebral Ischemia in Rats 50.1 Introduction 50.2 Methods 50.2.1 Animals and Hypoxic Preconditioning 50.2.2 Permanent MCAO and Infarct Volume Analysis 50.2.3 Western Blot Analysis 50.2.4 Statistical Analysis 50.3 Results 50.4 Discussion References 51: Time Series Tracking of Cerebral Microvascular Adaptation to Hypoxia and Hyperoxia Imaged with Repeated In Vivo Two-Photon Microscopy 51.1 Introduction 51.2 Methods 51.3 Results 51.4 Discussion References 52: Environmental Enrichment Improved Cognitive Performance in Mice under Normoxia and Hypoxia 52.1 Introduction 52.2 Methods 52.2.1 Animals, Environmental Enrichment, and Hypoxic Exposure 52.2.2 Measurement of Cognitive Function 52.2.3 Statistical Analysis 52.3 Results 52.4 Discussion References 53: Effect of Prolonged Pressure on Hemodynamics of Sacral Tissues Assessed by Diffuse Optical Imaging: A Pilot Study 53.1 Introduction 53.2 Methods 53.3 Results 53.4 Discussion 53.5 Conclusion References 54: In Phantom Validation of Time-Domain Near-Infrared Optical Tomography Pioneer for Imaging Brain Hypoxia and Hemorrhage 54.1 Introduction 54.2 Methods 54.3 Results and Discussion 54.3.1 No-Prior Reconstruction 54.3.2 Region-Based Reconstruction 54.4 Conclusions References 55: Online Noninvasive Assessment of Human Brain Death by Near-Infrared Spectroscopy with Protocol of O2 Inspiration 55.1 Introduction 55.2 Methods 55.3 Results 55.4 Conclusions References 56: Not Removing the Glossy White Cover from Adhesive INVOS Neonatal Sensors Affects the Oxygenation Measurement 56.1 Introduction 56.2 Methods 56.3 Results 56.4 Discussion References 57: Probe Design Optimization for Time-Domain NIROT “Pioneer” System for Imaging the Oxygenation of the Preterm Brain 57.1 Introduction 57.2 Method 57.3 Results 57.4 Discussion 57.5 Conclusion References Part V: Interstitium, Lymphatics and Blood 58: Effect of Blood Flow on Hemoglobin and Myoglobin Oxygenation in Contracting Muscle Using Near-Infrared Spectroscopy 58.1 Introduction 58.2 Methods 58.3 Results 58.4 Discussion References 59: Magnetoresistance Properties of Red Blood Cells in Plasma Combined with Several Magnetic Beads Passing Two Cu Electrodes 59.1 Introduction 59.2 Materials and Methods 59.3 Experimental Results and Discussion 59.4 Conclusions References 60: Measurement of Tissue Oxygen as a Novel Approach to Optimizing Red Blood Cell Quality Assessment 60.1 Introduction 60.2 Overview of Methods to Measure Oxygen in Tissues to Assess the Efficacy of RBC Preparations 60.3 EPR Measurements of Impact of RBC Preparations on Oxygen in Tissues: A Rat Blood Loss/Transfusion Experiment 60.4 Discussion and Conclusions References 61: Gene Expression of Prox-1 and Hif-1a in Primo Vessels Inside Lymph Vessels of the Rabbit 61.1 Introduction 61.2 Materials and Methods 61.3 Differentially Expressed Genes (DEGs) of Prox-1 and Hifl-a in PV 61.4 Prox-1 and Hif-1a Gene Expression Analysis of PV in LV of LPS- and AES-Treated Rabbits 61.5 Conclusions References 62: On the Feasibility of Pulse Wave Velocity Imaging for Remote Assessment of Physiological Functions 62.1 Introduction 62.2 Methods 62.2.1 Data Acquisition 62.2.2 Image Processing 62.3 Results and Discussion 62.4 Conclusions References Author Index Subject Index