Treatment Strategy for Unexplained Infertility and Recurrent Miscarriage

Description

This book offers a highly informative guide to treating unexplained infertility and recurrent miscarriage (RM). In particular, it provides detailed treatment strategies for infertility or RM derived from uterine circumstance such as chronic endometritis and perturbation of endometrial decidualization, as well as maternal immunological rejection of an embryo as semi-allograft. Unexplained infertility refers to those types that cannot be detected by the general screening test. The causes are sometimes detected in the course of treatment with assisted reproductive technology including IVF. However, some unexplained infertility is intractable even after intracytoplasmic sperm injection or repeated implantation of morphologically suitable embryos. Patients with unexplained RM also have a high likelihood of undetectable risk factors of miscarriage. As a result, gynecologists often repeatedly provide these couples with general treatments for infertility and miscarriage or even discontinue treatment because they cannot detect the reason, which places serious financial, physical and mental burdens on the couples affected. This book offers gynecologists essential insights into the pathological condition of unexplained infertility and RM, equipping them to identify it, explain it to patients, and consider further examinations and more aggressive fertility treatments. Front Matter ....Pages i-viii Front Matter ....Pages 1-1 Unexplained Infertility: Introduction (Keiji Kuroda)....Pages 3-5 Fertilization Failure (Takashi Yamaguchi, Keiji Kuroda, Atsushi Tanaka, Seiji Watanabe)....Pages 7-17 Tubal Function Abnormalities with Tubal Patency in Unexplained Infertility (Yuko Ikemoto, Keiji Kuroda, Yasushi Kuribayashi, Masato Inoue)....Pages 19-31 Implantation Failure 1: Intrauterine Circumstances and Embryo–Endometrium Synchrony at Implantation (Keiji Kuroda, Satoko Yamashita)....Pages 33-43 Implantation Failure 2: Immunomodulating Treatment for the Patients with Repeated Implantation Failures Caused by Immunological Rejection (Koji Nakagawa, Rikikazu Sugiyama)....Pages 45-60 Unexplained Infertility: Treatment Strategy for Unexplained Infertility (Keiji Kuroda, Asako Ochiai)....Pages 61-75 Front Matter ....Pages 77-77 Unexplained Recurrent Miscarriage: Introduction (Keiji Kuroda)....Pages 79-84 Previous Trial Studies of Unexplained Recurrent Miscarriage (Keiji Kuroda)....Pages 85-94 Lifestyle Habits and Pregnancy Loss (Keiji Kuroda)....Pages 95-104 Perturbation of Endometrial Decidualization (Keisuke Murakami, Keiji Kuroda, Jan J. Brosens)....Pages 105-114 Treatment Strategy for Unexplained Recurrent Miscarriage (Keiji Kuroda)....Pages 115-125