ENGLISH

Xenobiotic metabolism and disposition : the design of studies on novel compounds

By Illing , H. P

Book information

Publisher
CRC Press
Year
1989
ISBN
9780849361630, 084936163X
Language
english
Format
PDF
Filesize
65 MB (68491408 bytes)
Pages
220\229
Time added
2020-02-15 03:34:36
Clinical Trials;Drug Screening;Drug Evaluation;Dru

Description

Content: INTRODUCTION. The Rationale for and Timing of Drug Metabolism Studies. IN VIVO BIO-LOGICAL STUDIES. Aims. Bal-ance Studies. Whole Body Autoradiogra-phy. Surgical Tech-niques Used in Disposition and Metabolism Stud-ies. Afterword. EXTRAPOLATION OF DATA AND STUDIES IN MAN. Studies in Man with Potential Therapeutic Agents. Pharmacokinetics and Its Application to Drug Development. METABOLITE IDENTIFICA-TION AND IN VITRO STUDIES. Analytical Procedures for Metabolites: Metabolite Profiling and the Isolation and Identification of Metabolites. In Vitro Studies on Metabolism. Biochemical Studies on Induction, Inhibition, and Activation. Index.

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