PET/CT in Hodgkin’s Lymphoma (Clinicians’ Guides to Radionuclide Hybrid Imaging)
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This book is a pocket guide to the practice of PET/CT imaging of Hodgkin’s lymphoma. The role of PET/CT in Hodgkin’s lymphoma, the characteristic findings and patterns, and the advantages and limitations of this hybrid modality are all clearly described. In addition, information is provided on clinical presentation, diagnosis, staging, pathology, management, and conventional radiological imaging. A useful pictorial atlas is included at the end of the book. PET/CT in Hodgkin’s Lymphoma is published within the Springer series Clinicians' Guides to Radionuclide Hybrid Imaging, which is aimed at referring clinicians, nuclear medicine/radiology physicians, radiographers/technologists, and nurses who routinely work in nuclear medicine and participate in multidisciplinary meetings. Compiled under the auspices of the British Nuclear Medicine Society, the series is the joint work of many colleagues and professionals worldwide who share a common vision and purpose in promoting and supporting nuclear medicine as an important imaging specialty for the diagnosis and management of oncological and non-oncological conditions. Foreword Preface Acknowledgements Contents Contributors 1: Hodgkin Lymphoma 1.1 Epidemiology 1.2 Clinical Presentation 1.3 Diagnosis 1.4 Pathology and Classification 1.5 Staging 1.6 Prognostic Factors at Baseline 1.7 Nodular Lymphocyte Predominant Hodgkin Lymphoma Further Reading 2: Pathology of Hodgkin Lymphoma 2.1 NLPHL: Clinical, Biological, Morphological and Immunophenotipical Features 2.2 cHL: Clinical, Biological, Morphological and Immunophenotipical Features 2.3 cHL Variants 2.3.1 Nodular Sclerosis 2.3.2 Mixed Cellularity 2.3.3 Lymphocyte Rich 2.3.4 Lymphocyte Depleted Further Reading References 3: Management of Hodgkin Lymphoma 3.1 Baseline Evaluation 3.2 Historical overview of HL treatment 3.3 Upfront Treatment Modalities 3.4 Early Stage Favourable cHL 3.5 Early Stage Unfavourable cHL 3.6 Treatment of Advanced-Stage Disease 3.7 Follow-Up Evaluation 3.8 Management of Refractory and Relapsed Disease 3.9 Novel Agents 3.10 Management of NLPHL Further Reading 4: Radiological Imaging in Lymphoma 4.1 Introduction 4.2 Primary Diagnosis/Staging 4.3 Response Assessment 4.4 The Future References 5: 18F-FDG PET/CT in Hodgkin’s Lymphoma 5.1 Pretreatment Assessment 5.1.1 Staging 5.1.2 Prognostication 5.2 Interim Scanning 5.2.1 Prognostication 5.3 Response-Adapted Therapy 5.4 End of Treatment Scanning 5.5 PET Before High-Dose Chemotherapy or Transplant 5.6 Surveillance 5.7 Radiotherapy Planning 5.8 Combined Scanning of PET/CT with Contrast-Enhanced Diagnostic Quality CT 5.9 Scan Interpretation References 6: 18F-FDG PET/CT: Normal Variants, Artefacts and Pitfalls in Lymphoma 6.1 Introduction 6.2 General PET/CT Issues 6.2.1 False Positive 6.2.2 False Negative 6.3 Anatomy Based 6.3.1 Lymphatic Sites 6.3.1.1 Waldeyer’s ring 6.3.1.2 Lymph Nodes 6.3.1.3 Thymus 6.3.1.4 Spleen 6.3.2 Extralymphatic Sites 6.3.2.1 CNS 6.3.2.2 Thyroid 6.3.2.3 Lungs 6.3.2.4 Liver 6.3.2.5 GI 6.3.2.6 Renal Lymphoma 6.3.2.7 Bone Marrow 6.3.2.8 Skin Further Reading 7: PET/CT in Hodgkin’s Lymphoma: Teaching Cases 7.1 Case 1: Upstaging of Disease with PET/CT 7.1.1 Teaching Points 7.2 Case 2: Early Stage Unfavourable Disease 7.2.1 Teaching Points 7.3 Case 3: Splenic Involvement on PET/CT 7.3.1 Teaching Points 7.4 Case 4: Reactive Marrow Activity Pre-Treatment 7.4.1 Teaching Points 7.5 Case 5: Bone Marrow Involvement 7.5.1 Teaching Points 7.6 Case 6: Brown Fat Activity 7.6.1 Teaching Points 7.7 Case 7: Thymic Hyperplasia 7.7.1 Teaching Points 7.8 Case 8: Reactive Bone Marrow and Spleen Activation 7.8.1 Teaching Points 7.9 Case 9: Metabolic Remission 7.9.1 Teaching Points 7.10 Case 10: Interim PET Scan with Uptake Score of 3 7.10.1 Teaching Points 7.11 Case 11: Interim PET Scan with Uptake Score of 4 7.11.1 Teaching Points 7.12 Case 12: Interim PET Scan with Uptake Score of 5 7.12.1 Teaching Points 7.13 Case 13: False-Positive FDG Uptake at End of Treatment Scan 7.13.1 Teaching Points 7.14 Case 14: Relapsed Disease 7.14.1 Teaching Points 7.15 Case 15: Co-existing Sarcoidosis and Hodgkin’s Lymphoma 7.15.1 Teaching Points 7.16 Case 16: Spinal Cord Compression in Hodgkin’s Lymphoma 7.16.1 Teaching Points 7.17 Case 17: Incidental Focal Thyroid Activity on a Lymphoma Staging Scan 7.17.1 Teaching Points 7.18 Case 18: Management of Early Stage Hodgkin’s Lymphoma 7.18.1 Teaching Points 7.19 Case 19: Management of Early Stage Hodgkin’s Lymphoma 7.19.1 Teaching Points 7.20 Case 20: Suspected Relapse Following Treatment for Hodgkin’s Lymphoma-1 7.20.1 Teaching Point 7.21 Case 21: Suspected Relapse Following Treatment for Hodgkin’s Lymphoma-2 7.21.1 Teaching Point 7.22 Case 22: Interim PET/CT Scan Assessment 7.22.1 Teaching Points 7.23 Case 23: Immunotherapy for Refractory and Relapsed Hodgkin’s Lymphoma 7.23.1 Teaching Points 7.24 Case 24: Immunotherapy for Refractory and Relapsed Hodgkin’s Lymphoma 7.24.1 Teaching Points 7.25 Case 25: Post-transplant Lymphoproliferative Disorder 7.25.1 Teaching Points Index
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