Atlas of Lymphoscintigraphy and Sentinel Node Mapping: A Pictorial Case-Based Approach

Description

Although lymphoscintigraphy was originally introduced into clinical routine for identification of the cause of peripheral edema, more recently it has been widely applied for radioguided biopsy of the sentinel lymph node in patients with solid cancers. The procedure is now considered crucial for adequate planning of oncologic surgery in a growing number of cancers. This atlas presents a collection of richly illustrated teaching cases that demonstrate the clinical relevance and impact of lymphoscintigraphy in different pathologic conditions. After introductory chapters on the anatomy, physiology, and pathophysiology of lymphatic circulation, the role of lymphoscintigraphy in differential diagnosis of peripheral edema and characterization of intracavitary lymph effusions is addressed. The principal focus of the book, however, is on the use of lymphoscintigraphic mapping for radioguided sentinel node biopsy in cutaneous melanoma and cancers at a range of anatomic sites. The most commonly observed lymphoscintigraphic patterns are depicted, and anatomic variants and technical pitfalls of the procedure receive careful attention. The role of tomographic multimodality imaging is also considered. The atlas will be an excellent learning tool for residents in nuclear medicine and other specialists with an interest in the field. Front Matter....Pages i-xxiii The Anatomy and Physiology of Lymphatic Circulation....Pages 1-5 The Pathophysiology of Lymphatic Circulation in Different Disease Conditions....Pages 7-15 Methodological Aspects of Lymphoscintigraphy: Radiopharmaceuticals and Instrumentation....Pages 17-25 Methodological Aspects of Lymphoscintigraphy: Bicompartmental Versus Monocompartmental Radiocolloid Administration....Pages 27-38 Lymphoscintigraphy for the Differential Diagnosis of Peripheral Edema and Intracavitary Lymph Effusion....Pages 39-86 The Sentinel Lymph Node Concept in Oncologic Surgery....Pages 87-93 General Concepts on Radioguided Sentinel Lymph Node Biopsy: Preoperative Imaging, Intraoperative Gamma-Probe Guidance, Intraoperative Imaging, and Multimodality Imaging....Pages 95-110 SPECT/CT Image Generation and Criteria for Sentinel Node Mapping....Pages 111-119 Preoperative and Intraoperative Lymphatic Mapping for Radioguided Sentinel Node Biopsy in Breast Cancer....Pages 121-167 Preoperative and Intraoperative Lymphatic Mapping for Radioguided Sentinel Node Biopsy in Cutaneous Melanoma....Pages 169-198 Preoperative and Intraoperative Lymphatic Mapping for Radioguided Sentinel Node Biopsy in Head and Neck Cancers....Pages 199-223 Preoperative and Intraoperative Lymphatic Mapping for Radioguided Sentinel Node Biopsy in Non-Small-Cell Lung Cancer....Pages 225-229 Preoperative and Intraoperative Lymphatic Mapping for Radioguided Sentinel Node Biopsy in Cancers of the Gastrointestinal Tract....Pages 231-248 Preoperative and Intraoperative Lymphatic Mapping for Radioguided Sentinel Node Biopsy in Cancers of the Female Reproductive System....Pages 249-268 Preoperative and Intraoperative Lymphatic Mapping for Radioguided Sentinel Node Biopsy in Cancers of the Male Reproductive System....Pages 269-283 Preoperative and Intraoperative Lymphatic Mapping for Radioguided Sentinel Node Biopsy in Kidney and Bladder Cancers....Pages 285-293