Breast Cancer in the Post-Genomic Era

Description

Breast Cancer is the most common tumor in women and it is the second leading cause of cancer deaths worldwide. Due to breakthroughs in gene profiling, the knowledge of the pathophysiology of the mammary gland had greatly increased over the last decade. In Breast Cancer in the Post Genomic Era, Antonio Giordano, Nicola Normanno, and a panel of international authorities in their field provide a comprehensive approach to the biology, diagnosis, prevention, and treatment of human breast carcinoma. The book provides a comprehensive approach to breast cancer, describing the use of gene profiling techniques to distinguish specific features of individual carcinomas, as well as emerging novel therapeutic approaches to treatment. Additional chapters cover the use of transgenic mice to model human breast cancer and the role of the EGF-CFC family in mammary gland development and neoplasia. Breast Cancer in the Post Genomic-Era succeeds in looking at breast cancer pathogenesis, diagnosis, and treatment under a more comprehensive light, and is a valuable resource for any Radiation or Surgical Oncologist, Cancer Biologist or Pathologist. Front Matter....Pages i-xi The Genomic Basis of Breast Development and Differentiation....Pages 1-18 Mammary Glands, Stem Cells and Breast Cancer....Pages 19-38 The Genetics of Breast Cancer....Pages 39-54 Alterations in Cell Cycle Regulatory Genes in Breast Cancer....Pages 55-77 Neuregulins in the Nucleus....Pages 79-86 Role of the EGF-CFC Family in Mammary Gland Development and Neoplasia....Pages 87-102 Modeling Human Breast Cancer....Pages 103-121 Gene Expression Profiling in Breast Cancer....Pages 123-136 TGF-β Signaling....Pages 137-149 DNA Methylation in Breast Cancer....Pages 151-175 Signal Transduction Inhibitors in the Treatment of Breast Cancer....Pages 177-201 Integration of Target-Based Agents in Current Protocols of Breast Cancer Therapy....Pages 203-224 Back Matter....Pages 225-230