Platelet Rich Plasma in Orthopaedics and Sports Medicine

Description

This book provides a comprehensive, state-of-the art summary of platelet rich plasmas (PRPs) in the field of regenerative medicine. The book begins with an overview of the basic science behind PRP, describing the role of platelets and growth factors followed by the most important biological effects expected from the use of PRPs. Platelet Rich Plasma in Orthopaedics, Sports Medicine and Maxillofacial Surgery includes numerous contributions detailing the current use of PRPs in clinical practice. From the origins in oral and maxillofacial surgery, to the latest advances in orthopaedics and sports medicine including the use of Platelet Rich Growth Factors (PRGF) in muscle, bone, tendon, ligament and nerve injuries, this book provides a wide scope of the topic. The volume concludes with chapters from experts in biology, orthopaedics, oral and maxillofacial surgery, where the convergence of expertise is leading to unprecedented insights into how to minutely control the in vivo fate and function of PRGF. This book will provide a useful resource for physicians and researchers interested in learning more about this rapidly growing area of biomedical treatment. Front Matter ....Pages 1-11 Platelets at the Interface between Inflammation and Tissue Repair (Nurden A. T., Nurden P.)....Pages 13-27 Characterization of Plasma Rich in Growth Factors (PRGF): components and formulations (Anitua E., Prado R., Nurden A. T., Nurden P.)....Pages 29-45 Repair and Regeneration: Connecting the Dots Among Coagulation, Immune System, the Sensory Nervous System and Fibrogenesis (Padilla S., Sánchez M., Padilla I., Anitua E.)....Pages 47-63 Effects of Plasma Rich in Growth Factors on Cells and Tissues of Musculoskeletal System: from Articular Cartilage to Muscles and Nerves (S. Padilla, M. Sánchez, E. Anitua)....Pages 65-81 Molecular Intervention with Plasma-Rich Growth Factors to Enhance Muscle Perfusion and Tissue Remodeling in Ischemic Diseases (B. Pelacho, A. Pérez, F. Prósper)....Pages 83-97 Endoret® (PRGF®) Application in the Oral and Maxillofacial Field (E. Anitua, L. Piñas, H. M. Alkhraisat)....Pages 99-123 The Scientific Rationale to Apply Plasma Rich in Growth Factors in Joint Tissue Pathologies: Knee Osteoarthritis (Padilla S., Anitua E., Fiz N., Pompei O., Azofra J., Sánchez M.)....Pages 125-143 A New Approach to Treat Joint Injuries: Combination of Intra-Articular and Intraosseous Injections of Platelet Rich Plasma (Sánchez M., Anitua E., Delgado D., Sanchez P., Prado R., Prosper F. et al.)....Pages 145-161 Knee Osteoarthritis: One versus Two Cycles of PRGF Infiltrations Treatment (Vaquerizo V., Ruiz de Castañeda MM.)....Pages 163-173 PRGF on Sports-Related Ligament Injuries (Cugat R., Cuscó X., Seijas R., Barastegui D., Álvarez-Díaz P., Alentorn-Geli E. et al.)....Pages 175-189 Tendinopathy and its Treatment: the Rationale and Pitfalls in the Clinical Application of PRP (Wang J., Zhou Y., Nirmala X.)....Pages 191-209 Infiltrations of PRGF to Treat Ligament and Tendon Injuries in the Hip and Pelvis (Kraeutler MJ., Garabekyan T., Mei-Dan O.)....Pages 211-223 A Novel and Versatile Adjuvant Biologic Therapy in the Management of Neuropathies (Sánchez M., Anitua E., Delgado D., Garate A., Bilbao AM., Sánchez P. et al.)....Pages 225-239 PRGF Molecular Intervention: a Bridge from Spontaneity to Muscle Repair (Sánchez M., Anitua E., Aizpurua B., Delgado D., Sánchez P., Guadilla J. et al.)....Pages 241-257 Minimally Invasive PRGF Treatment for Low Back Pain and Degenerative Disc Disease (Kirchner F., Anitua E.)....Pages 259-275 Education and Standardization of Orthobiologics: Past, Present & future (Sampson S., Vincent H., Ambach M.)....Pages 277-287